Overview of DNA methylation in cancer epigenome - Nature
2023年4月28日 · During carcinogenesis, DNA methylation profoundly changes, specifically, there is a global loss of DNA methylation and increased DNA methylation at the promoters of suppressor genes.
Analysis of DNA methylation in cancer: location revisited
2018年4月17日 · Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers.
Integrating muti-omics data to identify tissue-specific DNA methylation ...
2024年7月18日 · Here, the authors predict DNA methylation at CpG sites for seven cancer types and investigate how these influence cancer risk.
The Role of DNA Methylation in Cancer - PMC - National Center …
Aberrant DNA methylation is a widespread phenotype in cancer, and identifying the specific alterations driving the tumor phenotype can guide therapeutic strategies. In a recent study, our group applied the concept of DNA methylation addiction …
Navigating the DNA methylation landscape of cancer
2021年6月10日 · Disruption of DNA methylation control mechanisms causes a variety of diseases, including cancer. Cancer cells are characterized by aberrant DNA methylation (i.e., genome-wide hypomethylation and site-specific hypermethylation), mainly targeting CpG islands in gene expression regulatory elements.
Methylomics and cancer: the current state of methylation …
2023年10月16日 · This review thus provides a resource for understanding the emerging role of epigenetic methylation in cancer, the use of methylation-based biomarkers in cancer detection, and novel methylation-targeted drugs.
The DNA methylation landscape in cancer - PubMed
2019年12月20日 · As one of the most abundant and well-studied epigenetic modifications, DNA methylation plays an essential role in normal development and cellular biology. Global alterations to the DNA methylation landscape contribute to alterations in the transcriptome and deregulation of cellular pathways.
DNA methylation profiles in cancer: functions, therapy, and beyond
2023年12月7日 · Widespread changes in DNA methylation typically occur in the early stages of tumor development, indicating the important role of abnormal DNA methylation. Identifying the functional consequences of abnormal DNA methylation is therefore crucial for improving tumor diagnosis, prognosis, and treatment 4, 5.
DNA methylation and cancer - PubMed
It is commonly known that inactivation of certain tumor-suppressor genes occurs as a consequence of hypermethylation within the promoter regions and a numerous studies have demonstrated a broad range of genes silenced by DNA methylation in different cancer types.
DNA methylation and cancer diagnosis - PubMed
2013年7月18日 · DNA methylation patterns are largely modified in cancer cells and can therefore be used to distinguish cancer cells from normal tissues. This review describes the main technologies available for the detection and the discovery of aberrantly methylated DNA patterns.
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