Docetaxel | C43H53NO14 | CID 148124 - PubChem
Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and promote to cell death.
Docetaxel - Wikipedia
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional group on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain instead of the benzamide in paclitaxel.
Docetaxel: Uses, Interactions, Mechanism of Action - DrugBank …
Docetaxel is a taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
Docetaxel - an overview | ScienceDirect Topics
The structure of docetaxel. The stabilization of tubulins following treatment with docetaxel is associated with cell cycle arrest, which leads to cell death through apoptosis and mitotic catastrophe [19] .
Docetaxel Structure - C43H53NO14 - Over 100 million chemical …
The 2D chemical structure image of docetaxel is also called skeletal formula, which is the standard notation for organic molecules. The carbon atoms in the chemical structure of docetaxel are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated ...
Chemical structure of docetaxel (Dtx). - ResearchGate
Docetaxel (DTX), a taxoid used to treat breast cancer, is a BCS-class-IV compound (low oral bioavailability, solubility and intestinal permeability).
Chemical structure of docetaxel and cabazitaxel.
Chemical structure of docetaxel and cabazitaxel. Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known for being the first-line therapy for breast cancer...
Docetaxel structure fragmentation. (a) Chemical structure of docetaxel …
As shown in Figure 2 (top), the product ion spectrum of docetaxel shows three major fragments at m/z 549.2095 (taxane nucleus (10- Analyses of docetaxel reference substance as well as cell...
Docetaxel | 114977-28-5 - ChemicalBook
2024年11月19日 · Docetaxel (CAS 114977-28-5) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
Definition of docetaxel - NCI Drug Dictionary - National Cancer Institute
A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death.