Exosome and exosomal microRNA: trafficking, sorting, and function
Exosomal miRNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal miRNAs, and briefly describe how exosomes and their miRNAs ...
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
2015年2月1日 · Recently, mRNAs and microRNAs (miRNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal miRNAs, since the miRNA profiles of exosomes may differ from those of the parent cells.
Recent advances in the roles of exosomal microRNAs (exomiRs) in ...
2023年5月1日 · Several molecular components of exosomes, including exosome proteins and microRNAs (miRNAs), are promising diagnostic biomarkers. These exosomes may carry genetic information by containing messenger RNA (mRNA) and miRNA. The miRNAs are small noncoding RNAs that regulate protein-coding genes by acting as translational repressors.
Roles and mechanisms of exosomal non-coding RNAs in human ... - Nature
2021年11月10日 · Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects...
Exosomal miRNAs: Biological Properties and Therapeutic Potential
Due to their ability to efficiently shuttle small molecules between cells, exosomes are an extremely promising therapeutic tool for numerous diseases. Alternatively, because of the pathogenic significance of exosomal miRNAs in an array of diseases, drug development focusing on targeting the release of exosomal miRNA contents has begun.
Exosomal miRNA: an alternative mediator of cell-to-cell …
2019年7月11日 · Mounting evidence show that miRNAs are loaded into exosomes and secreted by almost all types of cells. miRNAs are selectively sorted into exosomes, and transferred to recipient cells, where they manipulate cell function. Thus, exosomal miRNAs are believed to be an alternative cell-to-cell communication mediator.
Exosomal miRNA-mediated intercellular communications and ...
2023年8月21日 · This review aims to provide insights into the latest discoveries concerning how the immune system communicates internally and with other cell types, with a specific focus on research involving exosomal miRNAs in macrophages, dendritic cells, B lymphocytes, and T …
Exosomes as miRNA Carriers: Formation–Function–Future
The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.
Exosomal miRNA-mediated intercellular communications and ...
2023年8月21日 · The extracellular miRNAs transfer needs to occur via exosomes as it prevents degradation by free-floating RNases. In this review, we will focus on the questions surrounding the exosomal miRNA to understand their role in the crosstalk between the immune cells and the immunomodulatory effects of exosomal miRNA inside the tumor microenvironments.
Frontiers | The Role of Exosomes and Exosomal MicroRNA in ...
2021年1月11日 · Exosomal miRNA plays a role in post-transcriptional gene regulation upon uptake by neighboring or distant cell. It enters the target cell and combines with the target mRNA molecule based on partial sequence complementarity. miRNAs inhibit protein synthesis by forming miRISC, a complex with specific proteins.