Exosome and exosomal microRNA: trafficking, sorting, and function
Exosomal miRNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal miRNAs, and briefly describe how exosomes and their miRNAs ...
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
Feb 1, 2015 · Recently, mRNAs and microRNAs (miRNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal miRNAs, since the miRNA profiles of exosomes may differ from those of the parent cells.
Recent advances in the roles of exosomal microRNAs (exomiRs) in ...
May 1, 2023 · Several molecular components of exosomes, including exosome proteins and microRNAs (miRNAs), are promising diagnostic biomarkers. These exosomes may carry genetic information by containing messenger RNA (mRNA) and miRNA. The miRNAs are small noncoding RNAs that regulate protein-coding genes by acting as translational repressors.
Exosomal miRNAs: Biological Properties and Therapeutic Potential
Due to their ability to efficiently shuttle small molecules between cells, exosomes are an extremely promising therapeutic tool for numerous diseases. Alternatively, because of the pathogenic significance of exosomal miRNAs in an array of diseases, drug development focusing on targeting the release of exosomal miRNA contents has begun.
Exosomal microRNAs derived from mesenchymal stem cells: …
Sep 11, 2020 · Herein, we discuss some aspects of exosomal miRNAs derived from MSCs in the progression, diagnosis and treatment of various diseases. Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents.
Exosomal miRNA-mediated intercellular communications and ...
Aug 21, 2023 · The extracellular miRNAs transfer needs to occur via exosomes as it prevents degradation by free-floating RNases. In this review, we will focus on the questions surrounding the exosomal miRNA to understand their role in the crosstalk between the immune cells and the immunomodulatory effects of exosomal miRNA inside the tumor microenvironments.
The expression of exosomal and cellular miRNAs in predicting ...
Jan 9, 2025 · Exosomal miRNA possesses the potential to serve as a biomarker for cancer diagnosis and responses to chemotherapy.Identification of specific cellular and exosomal miRNAs related to oxaliplatin resistance to be targeted by miRNA-based interventions (e.g., anti-miRs, antagomiRs, locked nucleic acids, small molecules, and miRNA sponges) may be a ...
Exosomal miRNA: an alternative mediator of cell-to-cell …
Jul 11, 2019 · Mounting evidence show that miRNAs are loaded into exosomes and secreted by almost all types of cells. miRNAs are selectively sorted into exosomes, and transferred to recipient cells, where they manipulate cell function. Thus, exosomal miRNAs are believed to be an alternative cell-to-cell communication mediator.
Exosomal miRNA-mediated intercellular communications and ...
Aug 21, 2023 · This review aims to provide insights into the latest discoveries concerning how the immune system communicates internally and with other cell types, with a specific focus on research involving exosomal miRNAs in macrophages, dendritic cells, B lymphocytes, and T …
Comparison of miRNA transcriptome of exosomes in three …
Sep 11, 2023 · Our study provides sets of comparative transcriptomic data of cellular mRNA and exosomal miRNA from three categories of human tissue with three individual biological controls in studies of iPSCs...