Flecainide - StatPearls - NCBI Bookshelf
2023年8月8日 · Flecainide is predominantly used for atrial fibrillation and other supraventricular arrhythmias. Flecainide acetate is an oral class Ic antiarrhythmic drug (AAD) that blocks cardiac Na+ channels and received FDA approval in 1984.
Flecainide: Uses, Interactions, Mechanism of Action - DrugBank …
Flecainide is a class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).
Flecainide - Wikipedia
Flecainide is a medication used to prevent and treat abnormally fast heart rates. [1] . This includes ventricular and supraventricular tachycardias. [1] . Its use is only recommended in those with dangerous arrhythmias or when significant symptoms …
Use of Flecainide for the Treatment of Atrial Fibrillation
2020年4月1日 · Flecainide is indicated for patients with atrial flutter, paroxysmal supraventricular tachycardia, and the prevention of documented life-threatening ventricular arrhythmias.
Flecainide: Current status and perspectives in arrhythmia …
Flecainide acetate is a class IC antiarrhythmic agent and its clinical efficacy has been confirmed by the results of several clinical trials. Nowadays, flecainide is recommended as one of the first line therapies for pharmacological conversion as ...
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide …
2020年12月10日 · We synthesized N-methylated flecainide analogues (QX-flecainide and N-methyl flecainide) and showed that N-methylation reduces flecainide’s inhibitory potency on RyR2 channels incorporated into artificial lipid bilayers.
Flecainide How and When: A Practical Guide in Supraventricular ...
Flecainide is highly effective for the acute termination and for the chronic suppression of AF. An excellent safety profile is described in patients with minimal or no signs of structural heart disease while mounting promising evidence will be available in patients with cardiomyopathy.
Flecainide in clinical practice - PMC - PubMed Central (PMC)
Flecainide is used in paroxysmal supraventricular tachycardias (SVT), including atrial fibrillation (AF), atrioventricular re-entrant tachycardia (AVRT), and atrioventricular nodal re-entrant tachycardia (AVNRT) in patients without structural heart disease.
Frontiers | The Antiarrhythmic Mechanisms of Flecainide in ...
2022年3月8日 · Flecainide is a class IC antiarrhythmic drug blocking cardiac sodium channels. RyR2 inhibition is proposed as the principal mechanism of antiarrhythmic action of flecainide in CPVT, while it is highly debated. In this article, we review the current progress of this issue.
Mechanism of flecainide's antiarrhythmic action in ... - PubMed
Flecainide increased atrial ERP and reduced conduction velocity in a tachycardia-dependent manner. Doses of flecainide that converted AF resulted in larger changes in ERP than in conduction velocity, increasing the minimum path-length capable of …