Fucose - Wikipedia
Fucose is a hexose deoxy sugar with the chemical formula C 6 H 12 O 5. It is found on N -linked glycans on the mammalian, insect and plant cell surface. Fucose is the fundamental sub-unit of the seaweed polysaccharide fucoidan. [1]
Biological functions of fucose in mammals - PMC
2017年5月4日 · Fucose is a 6-deoxy hexose in the l -configuration found in a large variety of different organisms. In mammals, fucose is incorporated into N -glycans, O -glycans and glycolipids by 13 fucosyltransferases, all of which utilize the nucleotide-charged form, GDP-fucose, to modify targets.
Fucose: biosynthesis and biological function in mammals
2003年7月1日 · Fucose is a deoxyhexose that is present in a wide variety of organisms. In mammals, fucose-containing glycans have important roles in blood transfusion reactions, selectin-mediated leukocyte-endothelial adhesion, host–microbe interactions, and numerous ontogenic events, including signaling events by the Notch receptor family.
Unmasking Fucosylation: from Cell Adhesion to Immune …
2018年5月17日 · Fucose is necessary for many critical cell adhesion and signaling events. Genetic modulation or modulation by fucose-specific reagents has revealed exciting new biology and opened new opportunities for the treatment of human diseases.
Significance of fucose in intestinal health and disease
2021年1月12日 · Fucose mediates many host–microbe interactions including establishment of a healthy gut community, protection from pathogens, and prevention of inflammatory diseases. The graphical abstract, created by Aven Jones, depicts a microbe swimming within the intestine toward the human milk oligosaccharide lacto-N-fucopentaose.
Protein O-fucosylation: structure and function - PubMed
Fucose is a common terminal modification on protein and lipid glycans. Fucose can also be directly linked to protein via an O-linkage to Serine or Threonine residues located within consensus sequences contained in Epidermal Growth Factor-like (EGF) repeats and Thrombospondin Type 1 Repeats (TSRs).
Significance of fucose in intestinal health and disease
This carbohydrate is abundant in host gut mucosal surfaces, numerous microbial cell surface structures, and some dietary carbohydrates. Fucosylated oligosaccharides facilitate the establishment of a healthy microbiota and provide protection from infection.