Excretable IR-820 for in vivo NIR-II fluorescence cerebrovascular ...
2019年8月9日 · Results: We have found that IR-820 has considerable NIR-II fluorescence intensity, and shows increased brightness in serum than in water. Herein, we achieved real time and in vivo cerebrovascular functional imaging of mice with high spatial resolution and large penetration depth, based on IR-820 assisted NIR-II fluorescence microscopy.
New indocyanine green therapeutic fluorescence nanoprobes …
2022年4月1日 · In this study, new indocyanine green (IR820) was utilized as a fluorescence agent and a PTA on HeLa cells and subcutaneous cervical cancer models of mouse. To improve PTT effect and biocompatibility of IR820, the amphiphilic polymer Pluronic F-127 (F-127) was utilized to modify free IR820 molecules, to form IR820@F-127 nanoparticles (NPs) by ...
Fluorescence imaging guided CpG nanoparticles-loaded IR820 …
2019年7月1日 · IR820-hydrogel can be effective for hyperthermia to eliminate the primary tumor based on its comprehensive coverage and generated photothermal-induced tumor antigens for assisted immunotherapy. CpG self-crosslinked nanoparticles improved the immune response of adjuvant against melanoma without extra nano-carriers.
Rational synthesis of IR820–albumin complex for NIR-II fluorescence …
2022年4月21日 · IR820, an analog of FDA-approved indocyanine green, is a promising second near-infrared window (NIR-II) fluorescence probe with better NIR-II fluorescence stability and great clinical transformation potential. Moreover, its fluorescence can be further remarkably enhanced by the interaction with albumin. Therefore,
可排泄的 IR-820 用于体内 NIR-II 荧光脑血管成像和皮下肿瘤的光 …
在此，我们基于IR-820辅助NIR-II荧光显微镜，实现了高空间分辨率和大穿透深度的小鼠实时活体脑血管功能成像。 此外，IR-820成功用于体内肿瘤的NIR-II荧光成像和光热治疗，皮下肿瘤得到明显抑制或完全根除。 结论：由于IR-820在NIR-II光谱区具有相当大的荧光强度和良好的光热效应，生物相容性和可排泄性IR-820在临床实践中的功能性血管造影和癌症治疗诊断方面具有巨大的潜力。 Excretable IR-820 for in vivo NIR-II fluorescence cerebrovascular imaging and …
新吲哚菁绿IR-820辅助的近红外荧光成像和光热及协同治疗在肿瘤 …
2024年7月31日 · 新吲哚菁绿IR-820因其具有强近红外 (near infrared, NIR, 750~1700 nm)荧光特性、良好生物相容性、高光热转换效率及稳定性等优势，在NIR发光的有机荧光染料中脱颖而出，被广泛应用于生物医学成像、荧光标记、细胞实时监测、光热治疗等研究领域。 为更好地发挥IR 820的生物医学应用价值，研究人员用不同生物化学分子修饰IR-820来增强其荧光及光热特性，制备多种类的荧光纳米粒子，在基础生物医学成像与肿瘤光热治疗方面开展了众多研究。 总结 …
Fluorescence imaging guided CpG nanoparticles-loaded IR820 ... - PubMed
In this study, we designed CpG self-crosslinked nanoparticles-loaded IR820-conjugated hydrogel with dual self-fluorescence to exert the combined photothermal-immunotherapy. IR820-hydrogel can be effective for hyperthermia to eliminate the primary tumor based on its comprehensive coverage and generated photothermal-induced tumor antigens for ...
pH- and Enzyme-Sensitive IR820–Paclitaxel Conjugate Self …
2018年8月17日 · Herein, we, for the first time, combined IR820 and PTX in an “all-in-one” fluorescence imaging-guided chemo–photothermal therapy (PTT) platform by a rational design of a novel pH- and enzyme-sensitive IR820–PTX conjugate assembly.
Near-infrared fluorescing IR820-chitosan conjugate for …
At 5 μM, IR820 is sufficiently fluorescent to be used in cell imaging of healthy and cancer cells, and generates sufficient heat upon NIR laser exposure to create a cell growth inhibition and/or cytotoxic effect.
Indocyanine-type Infrared-820 Encapsulated Polymeric …
2022年3月28日 · NIR-II fluorescence cerebrovascular functional imaging was carried out by IR-820 assisted NIR-II fluorescence microscopy. Results: We have found that IR-820 has considerable NIR-II fluorescence intensity, and shows increased brightness in serum than in …