B 细胞免疫分型 | Abcam - Abcam中文官网
祖 b 细胞进一步发育为前 b 细胞，前 b 细胞可在其表面表达 b 细胞受体 (igμ)。 在骨髓中的发育最终得到初始 B 细胞，初始 B 细胞可表达识别抗原的 B 细胞受体（含 IgM 和 IgD）。
Natural IgM and the Development of B Cell-Mediated …
Most serum immunoglobulin M (IgM) is “natural IgM,” which is produced apparently spontaneously by a distinct subset of B cells requiring no exogenous antigenic or microbial stimuli. Natural IgM is an evolutionarily conserved molecule and reacts with a variety of epitopes expressed on both self- and non-self antigens.
Science报道 | 施一公团队首次揭示人源IgM-B淋巴细胞受体组装的 …
2022年8月19日 · 该论文首次报道了人源IgM同种型B细胞受体（IgM-BCR）的高分辨率三维结构，揭示了膜结合的IgM（mIgM）与Igα和Igβ异源二聚体复合物组装的分子机制，从而回答了B细胞受体如何组装这一重要科学问题，同时也为基于B细胞受体的免疫疗法提供了关键的结构基础。
B cell antigen receptors of the IgM and IgD classes are ... - AAAS
One of the most surprising findings of our nanoscale receptor study is the increased proximity of IgM-BCRs and IgD-BCRs on the surface of activated B cells. This juxtaposition of IgM-BCRs and IgD-BCRs was detected on B cell lines and on primary B cells of murine and human origin with three different activation protocols.
IgM and IgD B cell receptors differentially respond to …
Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how this could impose tolerance.
Biochemistry, Immunoglobulin M - StatPearls - NCBI Bookshelf
2022年12月19日 · IgM immunoglobulins are produced by plasma cells as part of the body's adaptive humoral immune response against a foreign pathogen. Resting mature yet naive, B lymphocytes express IgM as a transmembrane antigen …
Human IgM–expressing memory B cells - Frontiers
2023年12月7日 · The reprogramming of circulating B cells into the sMZ B–cell compartment does not favor one specific B–cell subset, but naive, IgM memory as well as class–switched memory B cells are susceptible to DLL1–NOTCH2–dependent in vitro induction of the sMZ B–cell phenotype and gene expression profile (100, 150).
IgM and IgD B cell receptors differentially respond to ... - eLife
2018年3月9日 · We propose a role for IgD in maintaining the quiescence of autoreactive B cells and restricting their differentiation into autoantibody secreting cells. To defend an organism against invaders such as viruses and bacteria, cells of the immune system need to recognize and respond to foreign microbes.
IgM memory B cells: specific effectors of innate-like and adaptive ...
Antigen-experienced IgM + B cells with mutated V genes have emerged as important effectors of both adaptive and innate-like immune responses. While their precise role in recall responses appear to differ according to the nature of the immunogen or the infectious agent, they are able to achieve rapid plasma cell differentiation, germinal center ...
B cell extracellular vesicles contain monomeric IgM that binds …
2023年9月15日 · We found that B cells from multiple cell lines and primary B cells produce EVs that display monomeric IgM on the surface and contain encapsulated monomeric IgM, which is independent of secreted pentameric IgM. Our data indicate EV IgM can bind antigen specifically, and EV IgM can be incorporated intracellularly into secondary cells.