Immunoglobulin M - Wikipedia
Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the first antibody to appear in the response to initial exposure to an antigen; [1] [2] causing it to …
Structure, Function, and Therapeutic Use of IgM Antibodies
Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to foreign antigens.
Structural insights into immunoglobulin M | Science - AAAS
2020年2月6日 · We report a cryo–electron microscopy structure of the Fc region of human IgM in complex with the J-chain and pIgR ectodomain. The IgM-Fc pentamer is formed asymmetrically, resembling a hexagon with a missing triangle. The tailpieces of IgM-Fc pack into an amyloid-like structure to stabilize the pentamer.
Structure and Function of Immunoglobulin M (IgM)
2024年7月19日 · Immunoglobulin M (IgM) is a complex molecule characterized by its large size and unique structural features. It is composed of five monomeric units, each resembling the basic structure of other immunoglobulins, but arranged in a distinctive pentameric formation.
Immunoglobulin M (IgM) – Properties, Structure and Functions
2024年1月23日 · Structure of Immunoglobulin M. IgM is a glycoprotein of 970KDa molecular weight comprising of basic heavy and light-chain antibody structure but exists in pentameric (secretory) and monomeric configurations. The IgM polymer is composed of subunits in which two heavy chains (µ) are covalently paired with two light chains (L) and a valency of 10
Immunoglobulin M (IgM)- Structure and Functions
2022年6月26日 · Immunoglobulin M (IgM) is an antigen receptor on B cells and the first antibody produced in an immune response. It is present both on B cells, and as a soluble molecule in the blood. Because of its large size (900 kDa), IgM is found primarily in the intravascular space i.e. in the bloodstream and also lymph fluid.
Abstract: Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to foreign antigens.
3D Structures of IgA, IgM, and Components - PMC
Here, we examine the 3D structures of IgA and IgM, including the J-chain and SC. Disulfide bridging and N -glycosylation on these molecules are also summarized. With the increasing information of structure–function relationships, IgA- and IgM-based monoclonal antibodies will be an effective option in the therapeutic field.
Structure, Function, and Therapeutic Use of IgM Antibodies
2020年10月13日 · Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to foreign antigens.
Structure, Function, and Therapeutic Use of IgM Antibodies - MDPI
2020年10月13日 · Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to foreign antigens.