Interleukin-12 and the regulation of innate resistance and ... - Nature
2003年2月1日 · Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and forms a...
Interleukin 12 (IL-12) Family Cytokines: Role in Immune Pathogenesis ...
Interleukin 12 (IL-12) family is comprised of 4 members, IL-12, IL-23, IL-27 and IL-35. IL-12, IL-23 and IL-27 are secreted by activated antigen presenting cells (APC) during antigen presentation to naïve T cells while IL-35 is a product of regulatory T and B cells [ 1 – 3 ].
Immunology of IL-12: An update on functional activities and
2020年12月11日 · As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells.
Interleukin-12: Functional activities and implications for disease
Interleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to …
What is IL-12 in the Immune System and What Does it Do?
Interleukin-12 (IL-12) is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Produced primarily by antigen-presenting cells (APCs) such as dendritic cells and macrophages, IL-12 has been implicated in linking the innate and adaptive branches of the immune system, thus exerting profound effects on host ...
The Immunobiology of the Interleukin-12 Family: Room for …
The IL-12 family of cytokines influences the outcome of cancer, infection, and inflammatory diseases. Stumhofer, Hunter, and Tait review the combinatorial biology inherent to this family and the recent clinical insights that underscore the critical role of these pathways in human disease.
Interleukin-12: an update on its immunological activities, signaling ...
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It is produced by antigen-presenting cells and plays a critical role in host defense against intracellular microbial infection and control of malignancy via its ...
Interleukin 12 a Key Immunoregulatory Cytokine in Infection ...
Interleukin 12 (termed IL-12p70 and commonly designated IL-12) is an important immunoregulatory cytokine that is produced mainly by antigen-presenting cells. The expression of IL-12 during infection regulates innate responses and determines the type ...
Structure and assembly of the human IL-12 signaling complex
2024年10月3日 · IL-12, composed of α subunit IL-12p35 and β subunit p40, is primarily produced by activated antigen-presenting cells. 4, 5 IL-12 mediates the heterodimerization of cell surface receptors IL-12Rβ1 and IL-12Rβ2, leading to the activation of intracellular JAK2 and TYK2 proteins, which phosphorylate each other and downstream STATs, mainly STAT4 ...
IL-12 family cytokines: immunological playmakers - Nature
2012年7月19日 · The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35.
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