Pericardial Anatomy, Interventions and Therapeutics: A …
2021年11月1日 · The pericardium is a dual-layered flask-shaped fibroserous sac enveloping the heart and proximal great vessels with a potential space created by the parietal and visceral layers (Figure 1). The outer fibrous layer is contiguous with the great vessels superiorly and the diaphragm inferiorly.
Perioperative implications of pericardial effusions and cardiac ...
The intrapericardial pressure is normally lower than the mean right atrial and right ventricular (RV) diastolic pressures. Under physiological conditions intrapericardial pressure equals the intrathoracic pressure and varies between +5 and –5 mmHg during spontaneous expiration and inspiration, respectively. 3
Intrapericardial Administration to Achieve Localized and Targeted ...
2024年8月20日 · Intrapericardial administration has been proposed as an alternative delivery route of pharmacological agents via the bilaminar sac of pericardium surrounding the heart. To date, intrapericardial administration has entailed the localized administration of a broad spectrum of therapeutic agents.
Intrapericardial treatment of autoreactive pericardial effusion …
Aims: To evaluate efficacy and safety of intrapericardial treatment with the crystalloid corticosteroid triamcinolone in autoreactive pericardial effusion. Methods and results: Two hundred and sixty consecutive patients with pericarditis/myopericarditis underwent pericardiocentesis, pericardioscopy (Storz-AF1101B1), and epicardial biopsy with ...
Pericardial disease: what the general cardiologist needs to know
Raised intrapericardial pressure can occur by three main mechanisms: (1) increased fluid within the intrapericardial space; (2) increased volume of the cardiac chambers; or (3) increased stiffness of the pericardium.
Intrapericardial (A) Versus Strictly Extrapericardial (B) Involvement ...
2024年9月27日 · Intrapericardial aortic rupture usually causes immediate, fatal, cardiac tamponade. Extrapericardial rupture may be less lethal, given the hemorrhage may be contained by surrounding structures and have no effect on the heart.
Minimally invasive delivery of therapeutic agents by hydrogel …
2021年3月3日 · In rodent models of myocardial infarction, we demonstrate that intrapericardial injection is an effective and safe method to deliver hydrogels containing induced pluripotent stem cells-derived ...
Intrapericardial therapy and diagnosis - Current Cardiology Reports
Diagnosis and treatment for the heart and virtually all its structures is becoming available via the pericardium. With or without pericardial effusion (formerly necessary for safe access), instruments that can enter the noneffusive pericardium are available and thoroughly tested experimentally, with human trials currently under way.
Intrapericardial Delivery of Cardiosphere-Derived Cells: An ...
2016年2月11日 · The intrapericardial delivery has been defined as an efficient method for pharmacological agent delivery. Here we hypothesize that intrapericardial administration of cardiosphere-derived cells (CDCs) may have an immunomodulatory effect providing an optimal microenvironment for promoting cardiac repair.
Access routes, devices and guidance methods for intrapericardial ...
This review covers these access techniques and how they have been applied to the delivery of drugs, cells, and biologicals, demonstrating the potential of intrapericardial delivery for treatments in cardiac arrhythmia, vascular damage, and myocardial infarction.