Therapeutic use and toxicity of high-dose methotrexate
2024年8月1日 · This topic review will cover the clinical use of high-dose MTX for treatment of malignancy, focusing on the prevention and management of toxicity. Intrathecal use of MTX and clinical use of low-dose and intermediate-dose MTX for both malignant and nonmalignant (eg, rheumatologic) conditions are covered elsewhere. DEFINITION OF HIGH-DOSE ...
Intrathecal Chemotherapy (IT Chemo) - OncoLink
What is intrathecal chemotherapy? Intrathecal (IT) chemotherapy is when chemotherapy is given directly into the CSF. It is used to prevent or treat cancers that are in the CSF. When a cancer is in the CSF, it may be called CNS (central nervous system) involvement.
Intrathecal methotrexate - Great Ormond Street Hospital
Methotrexate is a chemotherapy drug that is used to treat certain types of cancer and leukaemia. When given intrathecally, it prevents leukaemia cells entering the cerebrospinal fluid (CSF) around the spine and brain.
• Care should be taken if radiotherapy is given during or after intrathecal methotrexate therapy as it can exacerbate methotrexate toxicity • IT methotrexate will reach the blood stream and can have systemic effects
Comments: If IT (intrathecal) chemotherapy is to be administered by IR (interventional radiology) then please place a "Lumbar Puncture by Radiology" order panel under Meds & Orders. IT chemotherapy administered in clinic does NOT need a Lumbar Puncture order. Intrathecal Injections ☐ methotrexate PF in sodium chloride 0.9% 5 mL
Intrathecal methotrexate in combination with systemic …
Intrathecal injection of methotrexate (MTX) is a potentially effective method for treating glioma with LMD. Our team found that MTX can inhibit the growth of GBM cells by downregulating the Ras/MAPK/Myc/CD47 signaling pathway [11].
Methotrexate - StatPearls - NCBI Bookshelf
2023年8月16日 · Intrathecal overdoses require CSF drainage and exchange, steroids, antidotes, and suspension of the medications that interfere with methotrexate clearance (e.g., NSAIDs, salicylates, TMP, penicillin, warfarin, valproate, proton pump inhibitors, cyclosporin, cisplatin).
The neurotoxicity of methotrexate (MTX) is more severe when administered intrathecally (IT) than by the oral and intravenous (IV) routes, and has been reported also with administration of therapeutic doses of 12 or 15 mg. Prompt recognition and treatment are
Progressive Lower Extremity Paralysis Caused by Intrathecal MTX …
2023年10月30日 · Methotrexate (MTX) is commonly used in intrathecal chemotherapy for patients with acute lymphocytic leukemia (ALL) to prevent central nervous system (CNS) involvement. However, the use of MTX-based chemotherapy can lead to rare yet severe complications, such as MTX-induced myelopathy.
2024年10月9日 · Your doctor has prescribed intrathecal chemotherapy (which is cytotoxic or cell toxic treatment) for your condition. This means that you will have chemotherapy drugs given by injection into the fluid around the spinal cord by a lumbar puncture procedure. The chemotherapy drugs used are methotrexate and cytarabine arabinoside (ARA-C). Occasionally