Kinesin - Wikipedia
Most kinesins walk towards the plus end of a microtubule, which, in most cells, entails transporting cargo such as protein and membrane components from the center of the cell towards the periphery. [1] . This form of transport is known as anterograde transport.
Kinesin protein walking on microtubule - YouTube
2012年8月17日 · Kinesin protein walking on a microtubule in a cell
Walking the walk: how kinesin and dynein coordinate their steps
Two dimeric microtubule-based motor proteins, kinesin-1 and cytoplasmic dynein can take over one hundred steps without detaching from the track. In this review, we discuss how these processive motors coordinate the activities of their two identical motor domains so that they can walk along microtubules.
Kinesin: walking, crawling or sliding along? - Cell Press
Kinesin constitutes a large motor-protein superfamily (referred to as the KIF family) that transports cargoes within a cell by moving on microtubule filaments. The genome-sequencing project has revealed that there are 45 different kinesins in humans .
Kinesin Walking Narrated Version for Garland - YouTube
2011年4月7日 · I created this animation of the molecular motor "kinesin" walking along a protofilament of a microtubule in 1999 for the Ron Milligan and Ron Vale Science pa...
Kinesin: walking, crawling or sliding along? - PubMed
Kinesins are microtubule-based motor proteins that are involved in cargo transport and mitosis. They are called "motors" because they convert chemical energy to mechanical energy (i.e. force and motion). They use the energy of ATP hydrolysis for their enzymatic processes by …
Kinesin: walking or limping? - Nature Cell Biology
2003年12月1日 · Some kinesin motors can move along a microtubule for many hundred steps without dissociating. These motors are dimers, but precisely how the two motor domains are coordinated during stepping is...
Recently, con-ventional kinesin, which was the first-identified member of the family, has been shown to walk by swapping its two heads in a ‘hand-over-hand’ mechanism. There is also experimental evidence supporting an asymmetric walking of kinesin in which two identical heads of the motor take alternate slow and fast steps.
Kinesin: walking, crawling or sliding along? - Cell Press
Kinesins are microtubule-based motor proteins that are involved in cargo transport and mitosis. They are called ‘motors’ because they convert chemical energy to mechanical energy (i.e. force and motion). They use the energy of ATP hydrolysis for their enzymatic processes by walking on microtubules. However, the mechanism underlying their motion has …
MINFLUX dissects the unimpeded walking of kinesin-1 | Science
2023年3月9日 · We uncovered rotations of the stalk and the heads of load-free kinesin during stepping and showed that ATP is taken up with a single head bound to the microtubule and that ATP hydrolysis occurs when both heads are bound. Our results show that MINFLUX quantifies (sub)millisecond conformational changes of proteins with minimal disturbance.