- Leptin activates MAPK independent of SHP2 and also regulates phosphatidylinositol 3 kinase (PI3K) signaling through insulin receptor substrate (IRS) phosphorylation.pmc.ncbi.nlm.nih.gov/articles/PMC4166933/
Effects of the Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice …
- DOI: 10.3390/biom12030477
- 已发布: 2022/03/21
- Keywords: MAPK/ERK signaling pathway; cartilage; collag…
- Authors: Wenji Wang
- 页数: 1
Epidemiological data suggest that various noncommunicable diseases develop as a result of altered maternal metabolic and physiological status due to exposure to several adverse factors during pregnancy. However, evidence for intrauterine exposure factors and mechanisms underlying the origin of early...Leptin signaling - PMC
Leptin activates MAPK independent of SHP2 and also regulates phosphatidylinositol 3 kinase (PI3K) signaling through insulin receptor substrate (IRS) phosphorylation. Forkhead box O1 …
Regulation of mitochondrial metabolism by autophagy supports …
2024年1月16日 · Leptin is an adipokine secreted by adipose tissue, which promotes tumor progression by activating canonical signaling pathways such as MAPK/ERK.
Leptin Promotes the Proliferation and Neuronal Differentiation of ...
2023年10月13日 · We found that leptin has a neurogenic potential effect on NSCs, and may regulate the proliferation and neuronal differentiation of NSCs via MAPK/ERK and PI3K/AKT …
Human leptin activates PI3K and MAPK pathways in human
2001年9月15日 · Thus, leptin dose-dependently stimulates tyrosine and threonine phosphorylation of MAPK in mononuclear cells. In summary, the present work demonstrates …
Effects of the Leptin-Mediated MAPK/ERK Signaling Pathway on …
2022年3月21日 · Leptin signaling through leptin receptors can be mediated via the MAPK pathway. Therefore, we examined the expression of key proteins of the cartilage MAPK …
Melanocortin potentiates leptin-induced STAT3 signaling via …
This suggests that ligand-stimulated MC4R activates STAT3 through the MAPK pathway, although to a lesser extent than leptin-induced STAT3 activation. The ineffectiveness of the …
MAPK Erk5 in Leptin Receptor‒Expressing Neurons Controls
2019年12月1日 · Extracellular signal-regulated kinase 5 (Erk5), a member of the MAPK family, is specifically phosphorylated and activated by MAPK/Erk kinase-5. Although it has been …
Human Leptin Activates PI3K and MAPK Pathways in Human …
2001年9月15日 · Thus, leptin dose-dependently stimulates tyrosine and threonine phosphorylation of MAPK in mononuclear cells. In summary, the present work demonstrates …
Recent progress in leptin signaling from a structural perspective …
2023年9月1日 · Interactions between two leptin molecules and two LEPRs lead to phosphorylation of intracellular JAK2 kinases, which further activate five major downstream …
