IgE and mast cells in allergic disease - PMC - PubMed Central (PMC)
In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders.
IgE and mast cells in allergic disease | Nature Medicine
2012年5月4日 · In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest...
IgE and mast cells in allergic disease - PubMed
2012年5月4日 · In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders.
IgE, Mast Cells, Basophils, and Eosinophils - PMC
IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions.
Roles of IgE and Histamine in Mast Cell Maturation - PMC
Mast cells are activated upon immunoglobulin E (IgE)-mediated antigen stimulation, and release a wide variety of mediators, including histamine to trigger inflammatory responses. The surface expression levels of Fcε receptor I (FcεRI), a high affinity receptor of IgE, were found to be positively regulated by IgE.
Mast Cell Survival and Activation by IgE in the Absence of …
2005年10月1日 · Mast cells are not only major effector cells in allergy and host defense against parasites and bacteria but also important cellular components in other immune responses. Recent studies on the effects of monomeric IgE on mast cell survival and activation have made an impact on our view of the IgE binding to its high-affinity receptors, FcεRI.
IgE, mast cells, basophils, and eosinophils - Journal of Allergy …
IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions.
Allergy, Anaphylaxis, and Nonallergic Hypersensitivity: IgE, Mast Cells ...
IgE antibodies bind to type I high-affinity IgE receptors (FcεRI) on mast cells and basophils, sensitizing them to get triggered in a subsequent encounter with the cognate allergen. This promotes the release of a large variety of inflammatory mediators including histamine responsible for the symptoms of immediate hypersensitivity.
The role of mast cells in allergic inflammation - ScienceDirect
2012年1月1日 · When mast cells are activated by an allergen that binds to serum IgE attached to their FcɛRI receptors, they release cytokines, eicosanoids and their secretory granules.
IgE and mast cells: The endogenous adjuvant - ScienceDirect
2020年1月1日 · IgE and mast cells are known first and foremost for driving immediate hypersensitivity, the class of acute allergic reactions such as hives, wheezing, and anaphylaxis. These occur when allergen interacts with allergen-specific IgE bound to the mast cell via the high affinity IgE receptor, FcɛRI.