Methionine synthase - Wikipedia
Methionine synthase (MS, MeSe, MTR) is primarily responsible for the regeneration of methionine from homocysteine in most individuals. In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase).
Methionine Synthase - an overview | ScienceDirect Topics
Methionine synthase, an ubiquitously expressed enzyme, remethylates homocysteine back to methionine, thus conserving the carbon skeleton of this essential amino acid. MS employs, as methyl donor, 5-methyltetrahydrofolate, which is produced by the enzyme methylenetetrahydrofolate reductase.
甲硫氨酸合酶通过调节叶酸代谢而影响肿瘤发生的新机制
2021年12月5日 · 2021年11月17日， Nature Metabolism 杂志发表由普林斯顿大学 Joshua D. Rabinowitz 教授和麻省理工学院 Matthew G. Vander Heiden 教授分别领衔的“背靠背”文章—— Methionine synthase supports tumour tetrahydrofolate pools” 和 “Methionine synthase is essential for cancer cell proliferation in physiological ...
Methionine Synthase - an overview | ScienceDirect Topics
Methionine synthase (encoded by the gene Mtr) is a key enzyme in the one-carbon cycle that is required for the exclusive transfer of a methyl group from homocysteine to methionine (Shane and Stokstad, 1985).
Human B12-dependent enzymes: Methionine synthase and …
Methionine synthase catalyzes the transfer of a methyl group from N 5-methytetrahydrofolate to homocysteine, generating tetrahydrofolate and methionine. Cobalamin serves as an intermediate methyl group carrier and cycles between methylcobalamin and cob(I)alamin. Methylmalonyl-CoA mutase uses the 5′-deoxy-adenosylcobalamin form of the cofactor ...
甲硫氨酸合成酶 - 百度百科
甲硫氨酸合成酶 (methionine synthetase) 与 辅酶B12 结合，催化N5一 甲基四氢叶酸 的甲基转移到 半胱氨酸 上生成甲硫氨酸的酶。 存在于 大肠杆菌 、 产气杆菌 、 粪链球菌 等微生物中，从哺乳类动物和鸟类肝脏中也能分离得到此酶。
Methionine Synthase - an overview | ScienceDirect Topics
Methionine synthase catalyzes the methylation of homocysteine to form methionine, using 5-methyltetrahydrofolate as methyl group donor with formation of MeCbl as an intermediate. Activity of this enzyme requires the presence of a second protein, methionine synthase reductase, which maintains the enzyme-bound cobalamin prosthetic group in its ...
Identification and characterization of a bacterial core methionine synthase
2020年2月7日 · In our study we provide biochemical and genetic evidence that the locus cbdbA481 encodes a novel type of bacterial methionine synthase that appears to be an anciently derived MetE-related ...
Methionine synthase supports tumour tetrahydrofolate pools
2021年11月18日 · The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine...
M-CSA Mechanism and Catalytic Site Atlas - EMBL-EBI
Methionine synthase (MetH) is a cobalamin (vitamin B12) and zinc dependent enzyme that catalyses the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine.