NKG2D - Wikipedia
NKG2D ligands are induced-self proteins which are completely absent or present only at low levels on surface of normal cells, but they are overexpressed by infected, transformed, senescent and stressed cells.
Role of NKG2D and its ligands in cancer immunotherapy - PMC
In this review, we summarize the major findings regarding the antitumor immune response mediated by the NKG2D receptor and its ligands, and discuss the potential clinical applications of targeting the NKG2D/NKG2DL pathway for immunotherapy in cancer patients.
NKG2D and Its Ligands: “One for All, All for One” - PMC
Here, we will review recent studies on the NKG2D/NKG2D ligand biology to summarize and discuss the redundancy and/or diversity in ligand expression, regulation, and receptor specificity. Keywords: NKG2D ligands, NKG2D receptor, NK cells, virus infection, cancer
NKG2D and Its Ligands: "One for All, All for One" - PubMed
2018年3月12日 · Here, we will review recent studies on the NKG2D/NKG2D ligand biology to summarize and discuss the redundancy and/or diversity in ligand expression, regulation, and receptor specificity.
NKG2D ligands in tumor immunity | Oncogene - Nature
2008年10月6日 · The activating receptor NKG2D (natural-killer group 2, member D) and its ligands play an important role in the NK, γδ + and CD8 + T-cell-mediated immune response to tumors. Ligands for NKG2D...
The Role and Regulation of the NKG2D/NKG2D Ligand System in …
In humans, NKG2D binds to a family of eight proteins known as NKG2D ligands. NKG2D ligands are generally absent from the surfaces of healthy cells. By contrast, they are induced by various forms of cell stress, most notably DNA damage, which is very common in cancer cells.
Regulation of ligands for the NKG2D activating receptor
NKG2D ligands are regulated transcriptionally, at the level of mRNA and protein stability, and by cleavage from the cell surface. In some cases, ligand induction can be attributed to pathways that are activated specifically in cancer cells or infected cells.
Roles of the NKG2D immunoreceptor and its ligands - Nature
2003年10月1日 · NKG2D is a lectin-like type-2 transmembrane stimulatory immunoreceptor, which contains a charged transmembrane residue that enables it to interact with signalling adaptor molecules....
NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
2015年3月4日 · The discovery of the natural killer (NK) cell activating receptor NKG2D and its ligand MHC I chain-related molecule (MIC) expression on human cancer cells marks one of the most significant milestones in understanding NK cells in cancer immune surveillance in the last several decades (1–4).
Role of NKG2D and its ligands in cancer immunotherapy
2019年10月1日 · The NKG2D-NKG2D ligand (NKG2DL) pathway has been considered to be promising target for immunotherapy because of the selective expression of "stress-induced ligands" on tumor cells and the strong NK cell activating potency of NKG2D.