Precision psychiatry: a neural circuit taxonomy for depression …
In this Personal View, I focus on six circuits that have been implicated in dysfunctions expressed in depression and anxiety: default mode, salience, negative affect, positive affect (reward), attention, and cognitive control (figure 1).
Prefrontal cortex circuits in depression and anxiety ... - Nature
2020年2月21日 · Recently developed optogenetic and chemogenetic tools that allow high-fidelity control of neuronal activity in preclinical models have begun to elucidate the contributions of the PFC and its...
Toward Circuit Mechanisms of Pathophysiology in Depression
2020年5月1日 · In these circuit-focused frameworks, monoamine neuromodulators are still key players in depression pathophysiology, in that they exert a powerful influence on circuit function, but monoamine-targeting antidepressants are thought to achieve their therapeutic effects by engaging plasticity mechanisms, remodeling synaptic connectivity, and ...
Neural Circuits Underlying the Pathophysiology of Major Depression
2022年2月12日 · Recent research in patients and preclinical animal models has focused on identifying the neural circuits that mediate separable characteristics of depression, and connections between the prefrontal cortex (PFC) and subcortical regions such as the dorsal raphe nucleus (DRN) and the ventral tegmental area (VTA) have emerged as candidate targets.
Neural circuitry of depression. - APA PsycNet
The first section describes circuits linking specific structures that have been implicated in mood disorders, including the ventromedial prefrontal cortex (VMPFC), amygdala and other limbic structures, ventromedial striatum, and medial thalamus.
Role of the Brain’s Reward Circuitry in Depression: …
Here we focus on the nucleus accumbens (NAc), a critical component of the brain’s reward circuitry, in depression and other stress-related disorders. The prominence of anhedonia, reduced motivation, and decreased energy level in most individuals with depression supports the involvement of the NAc in these conditions.
Neuronal correlates of depression - PubMed
Accumulating evidence indicates that depression is a neural circuit disorder and that onset of depression may be located at different regions of the brain involving different transmitter systems and molecular mechanisms.
Mapping Neural Circuit Biotypes to Symptoms and
2022年3月15日 · In new data from primary and generalizability samples of depression and anxiety (N = 250), we demonstrated that overall disconnections within task-free salience and default mode circuits map onto symptoms of anxious avoidance, loss of pleasure, threat dysregulation, and negative emotional biases—core characteristics that transcend diagnoses—and ...
Neural Circuitry of Depression | Neurobiology of Mental Illness ...
This review of the neural systems that underlie mood disorders is divided into two main sections dealing with ( 1) the neuroanatomy of the neural circuits that have been implicated in mood disorders, largely taken from studies of non-human primates, and ( 2) observations on humans, largely taken from clinical studies.
A Neural Circuit-Based Model for Depression Anchored in a …
2019年1月1日 · Here, we synthesize evidence that subtypes of depression may arise from profiles of dysfunction in at least six neural circuits: default mode, salience, negative affective, reward, attention, and cognitive control circuits. We illustrate how a neural circuit framework for depression also informs more precisely tailored treatment choices and a ...