NRF2 controls iron homeostasis and ferroptosis through HERC2 …
2023年2月1日 · Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron homeostasis by controlling HERC2 (E3 ubiquitin ligase for NCOA4 and FBXL5) and VAMP8 (mediates autophagosome-lysosome fusion).
New insights into crosstalk between Nrf2 pathway and ferroptosis …
2024年11月18日 · Nrf2 plays a pivotal role in the regulation of essential genes involved in ferroptosis and is intimately linked to the progression of lung diseases. In lung cancer, the hyperactivation of...
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
NRF2 is a master regulator of the antioxidant response and has been shown to regulate the activity of several ferroptosis and lipid peroxidation-related proteins. These targets can be divided into three broad classes: iron/metal metabolism, intermediate metabolism, and GSH synthesis/metabolism.
NRF2, a Superstar of Ferroptosis - PubMed
2023年9月8日 · Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is key for cellular antioxidant responses, which promotes downstream gene …
NRF2, a Superstar of Ferroptosis - PMC - PubMed Central (PMC)
NRF2 can fight against ferroptosis by regulating its downstream antioxidant genes, but this also means that it maintains the survival of tumor cells while protecting normal cells. In the past decade, many studies have revealed that the activation of NRF2 in cancer cells promotes cancer progression [ 116 , 117 , 118 ] and metastasis [ 119 ], and ...
The regulation and function of Nrf2 signaling in ferroptosis
2024年7月17日 · In this review, we summarize the recent advances in the regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy and explore the prospect of combining Nrf2 inhibitors...
Targeting Nrf2 for ferroptosis-based therapy: Implications for ...
2023年10月1日 · Nrf2 can control the regulatory pathways of ferroptosis genes involved in glutathione biosynthesis, antioxidant responses, and lipid and iron metabolism, conferring ferroptosis evasion. Pharmacological inactivation of the Nrf2 pathway can sensitize cancer cells to ferroptosis induction, suggesting that modulating this pathway may represent a ...
NRF2, a Superstar of Ferroptosis - MDPI
2023年9月8日 · Therefore, targeting NRF2-related signaling pathways, to induce or inhibit ferroptosis, has become a great potential therapy for combating cancers, as well as preventing neurodegenerative and ischemic diseases. In this review, a brief overview of the research process of ferroptosis over the past decade will be presented.
Ferroptosis regulation through Nrf2 and implications for ...
Based on the research on the mechanism of ferroptosis in NDs, discuss the feasible strategies and related biomarkers of Nrf2 regulatory pathway in the diagnosis and treatment of ferroptosis-driven neurodegeneration.
Iron regulation in ferroptosis | Nature Cell Biology
2023年4月14日 · NRF2 is a transcription factor that confers resistance to oxidative stress and ferroptosis, a type of cell death that is mediated by free iron and lipid peroxidation. Here, Zhang and colleagues...