Oxygent™, a Perfluorochemical-Based Oxygen Therapeutic for …
2022年8月9日 · For over 15 years, Alliance Pharmaceutical Corp. (San Diego, CA) was developing Oxygent™, a concentrated and stabilized second-generation perfluorochemical (PFC) emulsion.
Oxygent developed and patented by Alliance comprise a sim-ple, efcient, high-yield process that can produce emulsion particles with an average median diameter of 0.16–0.18 μm [5], approximately one-fortieth the size of a red blood cell. Oxygent was formulated in phosphate-buffered saline with an
Blood substitute - Wikipedia
It aims to provide an alternative to blood transfusion, which is transferring blood or blood-based products from one person into another.
Use of Oxygent, a perfluorochemical-based oxygen carrier, as …
Oxygent is a stable concentrated perfluorochemical (PFC) emulsion being developed for use as a temporary oxygen carrier. In this application, PFC emulsions can be used to augment oxygen delivery during acute blood loss and thereby provide a margin of safety during hemodilution and surgical anemia.
Oxygent™, a Perfluorochemical-Based Oxygen Therapeutic for …
2006年12月31日 · Oxygent, like Oxyfluor, is a "second-generation" perfluorocarbon-based emulsion. Oxygent contains 60 g of the perfluorochemical perflubron per 100 ml of emulsion, and also contains a small...
Oxygent as a top load to colloid and hyperoxia is more effective …
In the presence of hyperoxia, Oxygent improved the amount of physically dissolved O2 in plasma and increased the contribution of physically dissolved O2 to global O2 delivery (P < 0.05) and thus whole body O2 consumption when compared with colloid alone (P < 0.05).
Therapeutic utility of Perfluorocarbon Oxygent in limiting the …
2024年11月4日 · Based on their small median size of ~ 0.2 μm and ability to carry O 2, PFC-based emulsions have been investigated for their role as oxygen therapeutics in traumatic brain injury (TBI),...
Perfluorocarbon-based oxygen delivery - PubMed
The basic properties of perfluorocarbons (PFCs) and PFC emulsions relevant to their use as oxygen delivery systems are briefly reviewed. The key issues related to the selection of an appropriate, readily excretable PFC and the engineering of a …
Alliance Pharmaceutical Corp. Updates Oxygent Clinical Development Plan
2007年11月27日 · Alliance is a development-stage pharmaceutical company that is currently focused on developing its lead product, Oxygent, which is based on its proprietary PFC technology. Oxygent is being developed as an intravascular oxygen carrier designed to augment oxygen delivery in surgical patients.
Alliance Pharmaceutical, Baxter to Collaborate on Oxygent
2000年5月12日 · Oxygent, a chemical-based oxygen carrier, enhances oxygen delivery to tissues. Used with a procedure called augmented-acute normovolemic hemodilution (Augmented-ANH), Oxygent could eliminate or reduce the need for blood transfusion during surgery.