PEDF - Wikipedia
Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti- tumorigenic, and neurotrophic functions.
PEDF and its roles in physiological and pathological conditions ...
Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles in many physiological and pathophysiological processes, ...
PEDF: a multifaceted neurotrophic factor - Nature
2003年8月1日 · Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as...
Pigment epithelium-derived factor and its role in ... - ScienceDirect
2022年9月1日 · Pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis, exerts antiangiogenic effects without affecting the structure and function of normal blood vessels. PEDF also has neurotrophic effects, which may be a potential direction for the future treatment of angiogenic diseases with lower side effects.
The effects of PEDF on cancer biology: mechanisms of action and ...
The potent actions of pigment epithelium-derived factor (PEDF) on tumour-associated cells, and its extracellular localization and secretion, stimulated research on this multifunctional serpin. Such studies have identified several PEDF receptors and downstream signalling pathways.
Pigment epithelium-derived factor (PEDF) is one of the most …
Objective: Pigment epithelium-derived factor (PEDF) is a multifunctional protein with neurotrophic and anti-angiogenic properties. More recently it became evident that PEDF is upregulated in patients with type 2 diabetes and also contributes to insulin resistance in mice.
Anti-tumor effects of pigment epithelium-derived factor (PEDF ...
In this review, we discuss the anti-tumor activities of PEDF and focus on its dual role as an inhibitor (e.g., angiogenesis) and as an inducer of various vital biological processes that lead to the therapeutic effect via different mechanisms of action.
Pigment epithelium-derived factor: clinical significance in estrogen ...
2014年11月28日 · Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of non-inhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and anti-metastatic properties.
The Various Roles of PEDF in Cancer - MDPI
2024年1月24日 · Pigment epithelium-derived factor (PEDF) is a versatile protein with potent effects against various cancers. It hinders cancer initiation and spread. This review highlights some of the molecular pathways involved in PEDF’s anticancer properties.
Pigment epithelium-derived factor (PEDF) is one of the most …
2010年10月12日 · Pigment epithelium-derived factor (PEDF) is a multifunctional protein with neurotrophic and anti-angiogenic properties. More recently it became evident that PEDF is upregulated in patients...