Palmitoylation - Wikipedia
Palmitoylation is the covalent attachment of fatty acids, such as palmitic acid, to cysteine (S -palmitoylation) and less frequently to serine and threonine (O -palmitoylation) residues of proteins, which are typically membrane proteins. [2] The precise function of palmitoylation depends on the particular protein being considered.
Understanding Protein Palmitoylation: Biological Significance …
This review summarizes the crucial role of palmitoylation in biological systems, the discovery of the DHHC protein family that catalyzes protein palmitoylation, and the development of methods for investigating the catalytic mechanism of PATs.
Protein lipidation in health and disease: molecular basis ... - Nature
2024年3月15日 · S-palmitoylation is capable of regulating protein trafficking and localisation, the hydrophobic palmitate covalently attached to the protein acts as a lipid anchor to increase protein ...
Palmitoylation: policing protein stability and traffic - Nature
The presence of palmitate on a protein affects how the protein interacts with lipids and proteins in a membrane compartment, and the reversibility of palmitoylation allows different modes of ...
A sticky situation: regulation and function of protein palmitoylation …
2021年10月6日 · Palmitoylation, akin to phosphorylation, is reversible, with palmitate cycling being mediated by substrate-specific enzymes. Palmitoylation is well-known to be highly prevalent among neuronal proteins and is well studied in the context of the synapse.
Palmitoylation: policing protein stability and traffic - PubMed
The presence of palmitate on a protein affects how the protein interacts with lipids and proteins in a membrane compartment, and the reversibility of palmitoylation allows different modes of trafficking between membrane compartments.
Protein palmitoylation in neuronal development and synaptic
Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects of neuronal protein trafficking and function.
Understanding Protein Palmitoylation: Biological Significance …
Protein palmitoylation is a widespread lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group.
Protein Palmitoylation in Leukocyte Signaling and Function
2020年10月27日 · This review provides the latest findings of palmitoylated proteins in leukocytes and focuses on the functional impact of palmitoylation in leukocyte function related to adhesion, transmigration, chemotaxis, phagocytosis, pathogen recognition, signaling activation, cytotoxicity, and cytokine production.
Emerging roles of protein palmitoylation and its modifying …
2022年5月9日 · Protein palmitoylation is an increasingly investigated form of post-translational lipid modification that affects protein localization, accumulation, secretion and function. Recently, emerging findings have revealed that protein palmitoylation is crucial for many tumor-related signaling pathways, such as EGFR, RAS, PD-1/PD-L1 signaling ...