Pamirs, highland region of Central Asia.The Pamir mountain area centres on the nodal orogenic uplift known as the Pamir Knot, from which several south-central Asian mountain ranges radiate, including the Hindu Kush, the Karakoram Range, the Kunlun Mountains, and the Tien Shan.Most of the Pamirs lie within Tajikistan, but the fringes penetrate Afghanistan, China, and Kyrgyzstan.