Platelet lysate - Wikipedia
Human platelet lysate (or hPL) is a substitute supplement for fetal bovine serum (FBS) in experimental and clinical cell culture. It is a turbid, light-yellow liquid that is obtained from human blood platelets after freeze/thaw cycle(s).
Human platelet lysate – A potent (and overlooked) orthobiologic
Platelet lysate (PL) is one of the proper sources of bioactive molecules found in platelet releasate. It is used in cell growth and proliferation and is a good alternative to fetal bovine serum. In recent years, the clinical use of PL has gained more attention since its preparations are acellular, thereby reducing concerns over immunogenicity ...
Platelet lysate: a promising candidate in regenerative medicine
Due to the presence of a large number of growth factors, platelet lysates have potential roles in wound healing, treatment of ocular graft-versus-host disease, osteoarthritis, Parkinson's disease, tendon regeneration, infertility, androgenetic alopecia, nerve repair and regenerative tissue, such as bone regeneration.
Platelet Lysate - an overview | ScienceDirect Topics
A platelet lysate involves the preparation of a platelet concentrate in which platelets are centrifuged into a pellet and exposed to freezing temperatures, thereby lysing the platelet cell membrane, releasing platelet growth factors from the alpha granule and reconstituting in plasma.
Platelet Lysate - SpringerLink
2024年5月3日 · This chapter will review the history of and rationale for the use of platelet lysate; review methods for producing platelet lysate; and discuss current and potential future clinical use of platelet lysate based upon information found in peer-reviewed medical journals.
Platelet lysate: A promising candidate in regenerative medicine
2021年2月5日 · In this review, we summarize that platelet lysates could be valuable candidates for the treatment of a variety of diseases in regenerative medicine. Platelet lysate composition. The composition...
人類血小板 (human Platelet Lysate, hPL)用於幹細胞治療之應用
2005年研究發現使用人類血小板裂解濃縮液(human Platelet Lysate, hPL)可以用來培養hMSC，對人體細胞治療臨床應用來說，HPL提供了一個新的選擇，利用HPL可以建立一個Xeno-free的細胞培養環境，在以細胞治療為目的細胞培養應用上相對更安全。
Human platelet lysate: Replacing fetal bovine serum as a gold …
2016年1月1日 · This review outlines the current knowledge about human platelet lysate as a powerful additive for human cell propagation and highlights its role as a prevailing supplement for human cell culture capable to replace animal serum in a growing spectrum of applications.
Human platelet lysate current standards and future developments
A state-of-the-art workshop focused on the use of human platelet lysate (HPL) for cell therapy. The meeting established that HPL is used mainly as an adjunct material for ex vivo expansion of mesenchymal stem/progenitor cells (MSCs), where it is successfully used as a …
Platelet Lysate: Uses, Interactions, Mechanism of Action
2020年9月21日 · Platelet lysate is an acellular compound composed of platelet proteins while also being void of cellular debris, thus making the lysate rich with growth factors. 1 It is extracted through lysis of the plasma membrane of platelets. Because white cell antigens are low in prepared lysate, there is a minimized likelihood of immune responses.