Enhancer selectivity in space and time: from enhancer–promoter ...
2024年2月27日 · In this Review, we first discuss current models of enhancer–promoter interactions in space and time and how enhancers affect transcription activation. Next, we discuss different mechanisms...
Mechanisms of enhancer action: the known and the unknown
2021年4月15日 · Enhancers are widely believed to physically contact the target promoters to effect transcriptional activation. However, our understanding of the full complement of regulatory proteins and the definitive mechanics of enhancer action is incomplete.
Increased enhancer–promoter interactions during ... - Nature
2024年3月20日 · A catalog of enhancer–promoter (E–P) interactions across ten mouse embryonic tissues, supported by in vivo functional experiments, shows that E–P proximity increases upon enhancer activation...
3D enhancer-promoter interactions and multi-connected hubs ...
2023年4月25日 · These highly connected promoters and enhancers, often described as “hubs” or “cliques,” have been associated with high transcriptional activity and are strongly enriched for genes and super-enhancers critical for cell identity, suggesting potentially important roles in gene regulation and cell fate. 56, 83, 84, 85 What is the nature of ...
Enhancer–promoter specificity in gene transcription: molecular ...
2024年4月25日 · This review summarizes the current understanding of enhancer-promoter interactions (EPIs), a key feature of genome structure, in gene regulation and disease.
Architectural and functional commonalities between enhancers and promoters
Promoter vs. Enhancer – a new comparison in the genomic era. Recent genome-wide evidence of transcribing enhancers observed in a wide range of cell types argues that the conventional definitions of the promoter and the enhancer must be revised.
Regulating specificity in enhancer–promoter communication
2022年4月1日 · In this review, we discuss mechanisms by which enhancers engage with promoters, including recent findings on the role of cohesin and the Mediator complex, and how this specificity in enhancer–promoter communication is encoded.
Dynamic modulation of enhancer‐promoter and promoter‐promoter …
2024年6月25日 · We suggest that the activities of transcription hubs are highly regulated through the dynamic rearrangement of enhancer-promoter and promoter-promoter connectivity during animal development. Enhancers are noncoding regulatory DNA segments that control the temporal and spatial specificity of gene transcription in development. [1] .
Molecular architecture of enhancer–promoter interaction
2022年2月1日 · This study examined the role of CTCF in enhancer-promoter interaction. Acute degradation of CTCF in mouse ES cells preferentially affected expression of genes located away (>100 kb) from their cognate enhancers. Promoter-proximal CTCF sites were suggested to play a key role in mediating long-range enhancer-promoter interaction.
In the loop: promoter–enhancer interactions and bioinformatics
2015年11月19日 · Enhancer–promoter regulation is a fundamental mechanism underlying differential transcriptional regulation. Spatial chromatin organization brings remote enhancers in contact with target promoters in cis to regulate gene expression. There is considerable evidence for promoter–enhancer interactions (PEIs).