Pyrvinium - Wikipedia
Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. [1] Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. [2] [3] Pyrvinium was identified as a potent Wnt inhibitor, acting through activation of Casein kinase CK1α. [4] [5]
Pyrvinium (oral route) - Mayo Clinic
2024年1月31日 · Pyrvinium is used to treat pinworms (enterobiasis). It will not work for other types of worm infections (for example, roundworms or tapeworms). Pyrvinium is available only with your doctor's prescription.
Pyrvinium: Uses, Interactions, Mechanism of Action - DrugBank …
2010年9月14日 · Pyrvinium is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinum's anti-cancer properties are currently under investigation.
Pyrvinium Advanced Patient Information - Drugs.com
Pyrvinium is used to treat pinworms (enterobiasis). It will not work for other types of worm infections (for example, roundworms or tapeworms). Pyrvinium is available only with your doctor's prescription.
Pyrvinium Pamoate: Past, Present, and Future as an Anti-Cancer …
2022年12月14日 · This review provides an in-depth analysis of the history of pyrvinium as a therapeutic, the rationale and data supporting its use as an anticancer agent, and the challenges associated with repurposing pyrvinium as an anti-cancer agent.
Pyrvinium | C26H28N3+ | CID 5281035 - PubChem
Pyrvinium is a quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.
Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a …
Here we show that the FDA-approved, anti-helminthic drug Pyrvinium attenuates the growth of WNT-dependent CRC cells and does so via activation of CK1α. Furthermore, we show that Pyrvinium can function as an in vivo inhibitor of WNT-signaling and polyposis in a mouse model of FAP: APCmin mice.
pyrvinium | Dosing & Uses - medtigo
pyrvinium is an anthelmintic medication primarily used to treat pinworm infections. Its action involves paralyzing and killing parasites like pinworms, preventing them from attaching to the intestinal wall and allowing them to be eliminated from the body.
An Anthelmintic Drug, Pyrvinium Pamoate, Thwarts Fibrosis and ...
2013年11月4日 · Herein, we show that an anthelmintic drug, Pyrvinium pamoate, which has been previously shown to compromise cancer cell survival under glucose starvation condition, also disables cardiac fibroblast survival specifically under glucose deficient condition.
Pyrvinium attenuates Hedgehog signaling downstream of …
2014年9月1日 · Recently, we identified the FDA-approved anti-pinworm compound pyrvinium as a novel, potent (IC50, 10 nmol/L) casein kinase-1α (CK1α) agonist. We show here that pyrvinium is a potent inhibitor of HH signaling, which acts by reducing the stability of the Gli family of transcription factors.