How RNA binding proteins interact with RNA: molecules and …
RNA binding proteins (RBPs) comprise a large class of over 2000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse.
A brave new world of RNA-binding proteins - Nature
2018年1月17日 · RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) and change the fate or function of the bound RNAs.
A large-scale binding and functional map of human RNA-binding proteins ...
2020年7月29日 · Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the Encyclopedia of DNA Elements (ENCODE) project...
RNA-binding proteins - Latest research and news - Nature
2024年12月18日 · RNA-binding proteins are proteins that bind to ribonucleic acid (RNA) molecules, are generally found in the cytoplasm and nucleus, and are important in forming ribonucleoproteins...
How RNA-Binding Proteins Interact with RNA: Molecules and ... - PubMed
2020年4月2日 · RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse.
RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, …
RNA-binding proteins (RBPs) are multi-faceted proteins in the regulation of RNA or its RNA splicing, localisation, stability, and translation. Amassing proof from many recent and dedicated studies reinforces the perception of RBPs exerting control through differing expression levels, cellular localization and post-transcriptional alterations.
FROM STRUCTURE TO FUNCTION OF RNA BINDING DOMAINS
Here, we review our current structural understanding of protein—RNA recognition mediated by four RNA-binding domains, the RNA recognition motif (RRM), the zinc-finger domain, the KH domain and the double-stranded RNA-binding motif (dsRBM).
RNA-binding proteins and their role in the regulation of gene ...
RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay.
A brave new world of RNA-binding proteins - PubMed
In this Review, we discuss these new RBPs and the emerging understanding of their unexpected modes of RNA binding, which can be mediated by intrinsically disordered regions, protein-protein interaction interfaces and enzymatic cores, among others.
Large-scale map of RNA-binding protein interactomes across the …
2024年9月19日 · mRNAs interact with RNA-binding proteins (RBPs) throughout their processing and maturation. While efforts have assigned RBPs to RNA substrates, less exploration has leveraged protein-protein interactions (PPIs) to study proteins in mRNA life-cycle stages.
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