Raltitrexed: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Raltitrexed is an antineoplastic Agents and folic acid antagonists. Raltitrexed inhibits thymidylate synthase (TS) leading to DNA fragmentation and cell death. It is transported into cells via a reduced folate carrier. Inside the cell Raltitrexed is extensively polyglutamated, which enhances thymidylate synthase inhibitory power and duration.
Raltitrexed (Tomudex) - Cancer Research UK
Raltitrexed is a chemotherapy drug. It is pronounced ral-tee-trex-ed. It is also known as Tomudex. It is a treatment for bowel (colorectal) cancer that has: You have raltitrexed on its own or with other cancer drugs. How does raltitrexed work? Raltitrexed is from …
Raltitrexed: current clinical status and future directions
2001年2月22日 · Raltitrexed (‘Tomudex’) monotherapy is a conveniently administered alternative to 5-fluorouracil (5-FU) in the first-line treatment of advanced colorectal cancer (CRC), and has single-agent activity in a variety of advanced solid tumours.
Raltitrexed - Memorial Sloan Kettering Cancer Center
What is this drug used for? It is used to treat colorectal cancer. It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take this drug? If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
Raltitrexed (Tomudex) | Guide to Mesothelioma Drug
2024年9月20日 · Raltitrexed, or Tomudex, has been effective against mesothelioma in combination with other chemotherapy drugs. Learn key results from raltitrexed clinical trials.
This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. What is this drug used for? It is used to treat colorectal cancer. It may be given to you for other reasons. Talk with the doctor.
Raltitrexed is an option for patients when the alternative chemotherapy drugs 5FU or Capecitabine cannot be used, or their use is felt to have a high-risk of complications. There are three patient groups where Raltitrexed is used:
Raltitrexed | C21H22N4O6S | CID 135400182 - PubChem
Raltitrexed is an antineoplastic Agents and folic acid antagonists. Raltitrexed inhibits thymidylate synthase (TS) leading to DNA fragmentation and cell death. It is transported into cells via a reduced folate carrier.
Raltitrexed (Tomudex®) - Andrew Gaya
Raltitrexed is a chemotherapy drug that is given as a treatment for some types of cancer. It is also known as Tomudex®. It is most commonly used to treat bowel cancer or advanced rectal cancer.
Raltitrexed - an overview | ScienceDirect Topics
Raltitrexed is a quinazoline folate analogue that acts as a direct and specific thymidylate synthase inhibitor, thereby inhibiting the synthesis of DNA. Raltitrexed enters the cell via the reduced-folate carrier and then undergoes polyglutamation.
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