Serine hydrolase - Wikipedia
Serine hydrolases are one of the largest known enzyme classes comprising approximately ~200 enzymes or 1% of the genes in the human proteome. [1] A defining characteristic of these enzymes is the presence of a particular serine at the active site, …
Serine Hydrolase - an overview | ScienceDirect Topics
2011年3月4日 · Serine hydrolases are characterized by a highly conserved serine residue in the active site, which is crucial in forming an intermediate enzyme–substrate ester bond when hydrolyzing ester, thioester, or amide bonds. You might find these chapters and articles relevant to …
The Metabolic Serine Hydrolases and Their Functions in …
The serine hydrolase (SH) superfamily consists of >200 enzymes in humans characterized by the presence of an active site serine that is used for the hydrolysis of substrates.
The Pharmacological Landscape and Therapeutic Potential of Serine ...
Here, we review the current state of pharmacology for mammalian serine hydrolases, including marketed drugs, compounds under clinical investigation, and selective inhibitors emerging from academic probe development efforts.
The expanding diversity of serine hydrolases - PMC
Serine hydrolases use a hydroxyl of a serine, assisted by one or more other residues, to cleave peptide bonds. They belong to several different families whose general mechanism is well known.
The Metabolic Serine Hydrolases and Their Functions in …
2011年6月23日 · Competitive Activity-Based Protein Profiling Identifies Aza-β-Lactams as a Versatile Chemotype for Serine Hydrolase Inhibition. Journal of the American Chemical Society 2012, 134 (11) , 5068-5071. https://doi.org/10.1021/ja300799t
The pharmacological landscape and therapeutic potential of serine ...
2012年1月3日 · Serine hydrolases are one of the largest and most diverse classes of enzymes found in eukaryotes and prokaryotes, including ∼ 240 members in humans. Several clinically approved drugs target...
Proteomic characterization of serine hydrolase activity and …
2013年11月15日 · The serine hydrolase family is one of the largest enzyme classes in humans and constitutes ~1% of predicted protein products from the eukaryotic genome. Serine hydrolases consist of greater than 100 serine proteases and approximately 110 esterases, lipases, peptidases and amidases .
A Superfamily-wide Activity Atlas of Serine Hydrolases in
2021年4月7日 · The serine hydrolase (SH) superfamily is, perhaps, one of the largest functional enzyme classes in all forms of life and consists of proteases, peptidases, lipases, and carboxylesterases as representative members.
Serine Hydrolase Active-Site Probes | Thermo Fisher Scientific
2011年6月1日 · Thermo Scientific Serine Hydrolase Probes are ActivX™ Fluorophosphonate (FP) and other tagged phosphonate probes to purify or assay serine hydrolase active sites using fluorescence, biotin-affinity, or mass spectrometry.