Soluble adenylyl cyclase - Wikipedia
Soluble adenylyl cyclase (sAC) is a regulatory cytosolic enzyme present in almost every cell. sAC is a source of cyclic adenosine 3’,5’ monophosphate (cAMP) – a second messenger that mediates cell growth and differentiation in organisms from bacteria to higher eukaryotes. sAC differentiates from the transmembrane adenylyl cyclase (tmACs ...
Structure, mechanism, and regulation of soluble adenylyl cyclases ...
2014年12月1日 · Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases
Soluble Adenylyl Cyclase - an overview | ScienceDirect Topics
The soluble adenylyl cyclase (sAC, adcy10) is a Class III adenylyl cyclase that is evolutionarily conserved from cyanobacteria to human (Buck, Sinclair, Schapal, Cann, & Levin, 1999; Chen et al., 2000). It catalyzes the cyclization of adenosine triphosphate (ATP) into 3′,5′-cyclic adenosine monophosphate (cAMP), the ubiquitous messenger ...
Soluble adenylyl cyclase, the cell-autonomous member of the …
2024年2月1日 · Soluble adenylyl cyclase (sAC) is an ancient but fascinating cell-autonomous regulator with multifaceted functions in cellular physiology. Its unique structure, localization, and regulation distinguish it from other members of the adenylyl cyclase family.
Soluble Adenylyl Cyclase in Health and Disease - PMC
Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC).
The role of soluble adenylyl cyclase in sensing and regulating ...
2024年4月6日 · Soluble adenylyl cyclase (sAC) differs from transmembrane adenylyl cyclases (tmAC) in many aspects. In particular, the activity of sAC is not regulated by G-proteins but by the prevailing bicarbonate concentrations inside cells.
Soluble adenylyl cyclase in health and disease - PubMed
Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC).
Soluble adenylyl cyclase regulates the cytosolic NADH/NAD - PubMed
2021年4月1日 · The evolutionarily conserved soluble adenylyl cyclase (sAC, ADCY10) mediates cAMP signaling exclusively in intracellular compartments. Because sAC activity is sensitive to local concentrations of ATP, bicarbonate, and free Ca<sup>2+</sup>, sAC is potentially an important metabolic sensor.
Kinetic Properties of “Soluble” Adenylyl Cyclase
“Soluble” adenylyl cyclase (sAC) is a widely expressed source of cAMP in mammalian cells that is evolutionarily, structurally, and biochemically distinct from the G protein-responsive transmembrane adenylyl cyclases.
Soluble adenylyl cyclase: A novel player in cardiac hypertrophy …
In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood.