tRF-33-P4R8YP9LON4VDP inhibits gastric cancer progression via …
2024年5月23日 · Over-expression of tRF-33 inhibited gastric cancer cell progression and metastatic viability, and induced cell apoptosis. Tumorigenicity in nude mice showed the suppressive characteristics of...
Emerging roles of tRNA-derived fragments in cancer - PMC
2023年2月13日 · The advance in high-throughput sequencing has contributed to the identification of increasing number of tRFs with critical functions in distinct physiological and pathophysiological processes. tRFs can regulate cell viability, differentiation, and homeostasis through multiple mechanisms and are thus considered as critical regulators of human dis...
The role and mechanism of action of tRNA-derived fragments in …
2023年3月24日 · Huang et al. found that tRF/miR-1280 inhibited colorectal cancer (CRC) cell growth and metastasis by directly interacting with the 3′UTR of its target gene, JAG2, and inhibiting Notch signaling .
A novel 3’tRNA-derived fragment tRF-Val promotes ... - Nature
2022年5月18日 · Here, we aimed to explore the carcinogenic roles of tRFs and tiRNAs in GC with RNA-sequencing technique, and found a novel 3’tRNA-derived fragment tRF-Val was significantly upregulated in GC ...
tRNA-derived fragments: Key determinants of cancer metastasis …
2024年3月1日 · Recent breakthroughs in cancer biology have discovered a group of small non-coding RNAs called tRNA-derived fragments (tRFs), which play a critical role in the metastatic behavior of various tumors. tRFs are produced from cleavage modifications of tRNAs and have different functional classes based on the pattern of these modifications.
Exosome-derived tRNA fragments tRF-GluCTC-0005 promotes
2024年1月30日 · Our results suggest that the key of PDAC liver metastasis is the activation of HSCs through upregulation of WDR1 by tRF-GluCTC-0005 in exosomes, which mediates the infiltration of MDSCs to form...
Role of tRNA-derived fragments in cancer: novel diagnostic and ...
2020年2月1日 · tRF-3s play a fundamental role in tumorigenesis and development. Some tRF-3s have similar functions to known miRNAs and piRNAs, binding to Ago or Piwi proteins and playing a regulatory role in tumor, while others affect proliferation, apoptosis and metastasis of tumor cells through regulation of ribosomal proteins and oncogenes.
A novel tRNA-derived fragment tRF-17-18VBY9M works as a …
2024年5月20日 · Results. The Chi-square test demonstrated that high-expressed tRF-17-18VBY9M was closely associated with the T stage, tumor node metastasis stage (TNM), lymph node metastasis, and neurological/vascular invasion.
tRNA-derived fragments (tRFs) in cancer | Journal of Cell ... - Springer
2022年8月29日 · In a recent report Tong et al. investigated overexpression of tRF-3017A in gastric cancer and its association with metastatic disease. They determined that tRF-3017A works as a microRNA interacting with Argonaute family proteins participating in …
TRF-20-M0NK5Y93 suppresses the metastasis of colon cancer …
2021年1月15日 · tRNA-derived fragments (tRFs) are derived from corresponding tRNAs and have been shown by several studies to be novel biological markers for tumour diagnosis and therapy. However, until now, the effects of tRFs on the progression of colorectal cancer (CRC) and especially on the epithelial-to-mesench ….