Telomere - Wikipedia
Telomeres are non-coding, repetitive sequences located at the termini of linear chromosomes to act as buffers for those coding sequences further behind. They "cap" the end-sequences and are progressively degraded in the process of DNA replication.
Telomere
2024年12月14日 · A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming frayed or tangled. Each time a cell divides, the telomeres become slightly shorter.
Telomere biology: from disorders to hematological diseases
Telomeres are non-coding nucleoprotein structures that protect the ends of eukaryotic chromosomes by discriminating natural ends from regular incidental DNA breaks (Figure 1 ). In this manner, telomeres prevent undesirable end-to-end fusion, nucleolytic degradation, and genomic instability.
Telomere Biology and Telomere Diseases: Implications for …
2010年1月30日 · For research in hematology and oncology, telomere biology could be assessed as a risk for secondary malignancies and in graft-versus-host disease, for progression in a variety of blood cancers, and as potentially modifiable by hormone replacement strategies.
Human telomere biology: A contributory and interactive factor
Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. Telomere attrition can lead to potentially maladaptive cellular changes, block cell division, and interfere with tissue replenishment.
Biochemistry, Telomere And Telomerase - StatPearls - NCBI Bookshelf
2022年12月11日 · Functions of telomeres include protecting the ends of the DNA from binding to one another and to itself, allowing for complete chromosomal replication, and serving as a molecular timer by controlling the lifespan of a eukaryotic cell.
Telomere Biology and Human Phenotype - PMC - PubMed …
Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro.
Center for Individualized Medicine - Telomere Biology Disorders
Telomere biology disorders, also called telomeropathies, are a group of rare genetic conditions characterized by telomeres that are longer or shorter than usual. Even though telomere biology disorders are genetic, symptoms can appear in both kids …
Genetics of human telomere biology disorders - Nature
2022年9月23日 · Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that prevent the activation of DNA damage response and repair pathways. Numerous factors localize at...
Telomere and telomerase biology - PubMed
Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special structures that cap chromosome ends to prevent degradation by nucleolytic attack and to distinguish chromosome termini from DNA double-strand breaks.