Thymidylate synthase - Wikipedia
Thymidylate synthase (TS) (EC 2.1.1.45) [5] is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage. [6] [7]
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase is an enzyme which catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate or thymidylate) …
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase (TS) catalyzes the conversion of dUMP to dTMP, a rate-limiting step in DNA synthesis. Inhibition of TS results in depletion of cellular nucleotide pools [85].
Structural and Functional Characterization of the Human Thymidylate …
Thymidylate synthase (TS, EC 2.1.1.45) is a ubiquitous enzyme that catalyses the reductive methylation of 2’-deoxyuridine-5’-monophosphate (dUMP) to 2’-deoxythymidyne-5’-monophosphate (dTMP) using N5, N10 -methylenetetrahydrofolate (mTHF) as cofactor. In human cells, TS provides the only synthetic source of dTMP necessary for DNA biosynthesis.
Thymidylate synthase structure, function and implication in …
Thymidylate synthase (TS or ThyA) has long been considered as one of the best-known drug targets in the anti-cancer area, after which old and new drugs, such as 5-fluoro uracil and the anti-folate ZD1694, have been introduced into chemotherapy to treat solid tumours.
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase (TS) is an enzyme present in mammalian cells which catalyzes the reductive methylation of deoxyuridylate by 5,10-methylene-5,6,7,8-tetrahydrofolic acid to form thymidylate (dTMP) and dihydrofolic acid.
Structural analyses of human thymidylate synthase reveal a site …
Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival. Inhibition of human TS (hTS) has been extensively investigated for cancer chemotherapy, but several aspects of its activity and regulation are still uncertain.
The catalytic mechanism and structure of thymidylate synthase
Thymidylate synthase (TS, EC 2.1.1.45) catalyzes the reductive methylation of dUMP by CH2H4folate to produce dTMP and H2folate. Knowledge of the catalytic mechanism and structure of TS has increased substantially over recent years.
Targeting Nuclear Thymidylate Biosynthesis - PMC
Thymidylate synthase (TYMS) utilizes 5,10-methylene-tetrahydrofolate as a cofactor in the conversion of dUMP to dTMP (Figure 1), oxidizing tetrahydrofolate to dihydrofolate. Dihydrofolate reductase (DHFR) catalyzes the NADPH-dependent reduction of …
7298 - Gene ResultTYMS thymidylate synthetase [ (human)]
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents.
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