VX (Nerve Agent) - an overview | ScienceDirect Topics
2020年8月20日 · In particular, the classically described G-agent nerve “gases” sarin (GB), GD, and tabun (GA) possess sufficiently high vapor pressures and volatilities to produce lethal vapor concentrations at room temperature. 9, 10 Another organophosphate nerve agent, VX, is the most potent chemical warfare agent; a single droplet of VX on the skin can ...
Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4 ...
2023年6月5日 · VX-150, an analgesic developed by Vertex pharmaceuticals, has completed three positive proof-of-concept studies in phase II clinical trials for patients with acute pain following bunionectomy surgery, osteoarthritis or small fiber neuropathy and validated the potential of Na V 1.8 channel inhibitors for pain relief. However, VX-150 displayed ...
VX (Nerve Agent) - an overview | ScienceDirect Topics
2019年4月30日 · Agent VX, a phosphonic acid ester with a sulfur substituent, was industrially synthesized in the United Kingdom in the early 1950s; the code letter “V” is a reported reference to “venom or venomous” (Sidell et al., 1997). Other, less well-characterized V-series compounds include Vx, VE, VM, and VG (trade name Amiton when commercially ...
Evaluation of the possibility of binary synthesis of VX by …
2020年10月1日 · The author proposed the possibility of binary synthesis of VX with the reaction conditions shown in Fig. 2a in the assassination in Malaysia. The starting materials for this reaction are O -ethyl methylphosphonothioate (EMPSH) and 2- (diisopropylamino) ethyl chloride (DECl). We calculated the reaction pathway of the VX synthesis reactions with ...
VX-765 prevents intestinal ischemia-reperfusion injury by …
2022年4月1日 · VX-765 reduced IIRI-induced oxidative stress and inflammatory response both in vivo and in vitro, while it decreased the levels of TNF-α, IL-6, IL-1β as well as the modified Park/Chiu scores. The optimal concentration of VX-765 for the in vitro studies was 10 μM. Moreover, VX-765 inhibited the nuclear translocation of P65, reduced oxidative ...
Adsorption of organophosphate nerve agent VX on the (101) …
2022年2月1日 · The length of the VX oxygen-phosphorus double bond in this adsorbed complex is nearly equal to its length in the isolated VX molecule, ∼ 1.5 Å. In addition to the dative bond formed in the VX/(101) complex, there are several surface-adsorbate CH · · · O hydrogen bonds with distances between interacting units in the range of ∼ 2.4–2.
Oxidative detoxification of nerve agent VX simulant by …
2021年2月1日 · Although Sarin, Soman and VX all belong to organophosphorus esters, VX is more toxic with a lethal dose of 0.0096 mg/m 3 and its detoxification is more challenging due to the existence of P-S bond [21]. To date, VX is mainly detoxified by stoichiometric reactions, while its catalytic detoxification and mechanistic studies are rarely studies [22 ...
Russian VX - ScienceDirect
2015年1月1日 · Structural formula of Russian VX. RVX is a colorless transparent liquid resembling glycerol in mobility, with a boiling point of 300.0ºC, melting point of 35.0ºC, ρ20 of 1.0083 g/cm 3, and volatility of C max20 0.0105 mg/dm 3. The agent is poorly soluble in water (less than 5% at 20°C) and highly soluble in organic solvents.
VX-970, selective inhibitor of ataxia telangiectasia and Rad3 …
2015年3月1日 · VX-970 is a potent and selective inhibitor of ATR with a Ki < 0.2 nM and intracellular IC50 of 19 nM.Results : VX-970 substantially increases the cytotoxic activity of multiple DNA damaging agents in a broad panel of tumor cell lines, with minimal increase in non-tumor cell cytotoxicity. VX-970 markedly synergizes with cytotoxic agents in mouse ...
Anchoring the quantification of VX and Russian VX using portable …
2021年10月1日 · The yield from the conversion of 1 ng of VX to VX-G was estimated to be 0.47 ng however the reported experimental yield was 0.38 ng (80% yield) for the method executed. Here, we report an effective approach for quantifying the derivatized nerve agents VX-G (O-ethyl methylphosphonofluoridate) and RVX-G (O-isobutyl methylphosphonofluoridate ...