Leukoencephalopathy with vanishing white matter - Wikipedia
Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the translation initiation factor eIF2B: EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5.
Vanishing white matter disease - UpToDate
2024年5月15日 · VWM disease is a chronic and progressive white matter disorder (leukodystrophy) characterized by a variable phenotype, typically with prominent ataxia and spasticity in the classic form. VWM is often exacerbated by infection, head …
Vanishing White Matter Disease - Hunter’s Hope
Vanishing White Matter Disease (VWM) is one of more than 50 conditions that affect the white matter, or myelin, of the brain known collectively as Leukodystrophies. VWM, also known as Childhood Ataxia with Central Nervous System Hypomyelination (CACH), is an extremely rare neurological condition that destroys myelin, the brain’s white matter ...
Vanishing White Matter Disease | Kennedy Krieger Institute
Vanishing white matter disease (VWM) is a rare autosomal recessive leukodystrophy, which means both copies of the affected gene in each cell have mutations.
Vanishing White Matter Disease - United Leukodystrophy Foundation
Vanishing White Matter Disease (VWM) is a genetic disorder that affects the nervous system and causes neurologic symptoms. Although initially recognized as a disease of young children, it is now known that the disease has a highly variable course with a wide range in severity.
What Is Vanishing White Matter Disease? - UPMC Children's ...
VWM disease is an inherited brain condition caused by a faulty gene. Symptoms often start between ages 2 and 6. Learn about VWM disease care at Children’s.
Vanishing white matter disease | Radiology Reference Article ...
2024年7月4日 · Vanishing white matter disease (VWM), also known as childhood ataxia with central hypomyelination (CACH), is a rare, genetic leukoencephalopathy due to mutations in EIF2B subunit mutations, typically appearing as extensive white …
Clinical Trial: Vanishing White Matter - Calico
Vanishing White Matter (VWM) is an ultra-rare genetic condition that causes the deterioration of white matter in the brain and permanently affects the transmission of nerve signals to the rest of the body.
The VWM Families Foundation – Supporting Vanishing White ...
Vanishing White Matter disease (VWM) is a very rare neurological condition that destroys myelin, the brain’s white matter. In doing so, it permanently affects transmission of brain signals to the rest of the body. VWM primarily affects children and is untreatable, incurable and terminal.
Core protocol development for phase 2/3 clinical trials in ...
2023年8月17日 · Background: The leukodystrophy "Vanishing White Matter" (VWM) is an orphan disease with neurological decline and high mortality. Currently, VWM has no approved treatments, but advances in understanding pathophysiology have …