Epitope - Wikipedia
Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of autoimmune diseases) are also epitopes. [1] The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their structure and interaction with the paratope. [2]
Epitope | Description & Function | Britannica
binding of antibodies and antigenic determinants The antigenic determinants, or epitopes, on the surface of an antigen bind to specific sites on an antibody. The hinge region of an antibody molecule opens and closes to allow better binding between the …
What is an Epitope? - News-Medical.net
2021年5月10日 · Mapping epitopes is important for developing effective vaccines, diagnostics, and therapeutics. It helps identify the epitope site and elucidate the antibody’s binding mechanism.
Epitopes: Types, Function, Epitope Spreading - Microbe Online
2021年6月1日 · Types of Epitopes. The antigenic determinants (epitopes) are divided into two categories based on their structures and interaction with the paratope. Linear epitopes; Conformational epitopes; Linear and conformational B-cell epitopes.
Epitope - an overview | ScienceDirect Topics
Generally, epitopes are thought of as 3D surface features of a protein; however, linear epitopes are an exception. These are determined by a single amino-acid sequence, that is, the primary structure, rather than the tertiary structure.
Epitope - an overview | ScienceDirect Topics
In this review, we will focus on T cell epitopes, as this is our principal area of expertise. We will further focus on the epitopes recognized by classical alpha-beta TCR receptors, and restricted by conventional HLA molecules.
12.2: Antigens and Epitopes - Biology LibreTexts
2023年8月31日 · How is the body able to distinguish epitopes of microorganisms from “self” epitopes present as a part of our body? What is the difference between how B-lymphocytes and T-lymphocytes recognize antigens?
IEDB.org: Free epitope database and prediction resource
2024年12月15日 · Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.
Defining epitopes: It's not as easy as it seems - Nature
1999年10月1日 · A major theme in biomedical research and biotechnology is the definition of sites involved in noncovalent interactions, often generically referred to as epitopes.
What is an Epitope? - AllTheScience
2024年5月21日 · T cell-activating epitopes are those which have been processed by immune cells called antigen-presenting cells, or APCs. When an APC processes epitopes, it does so by ingesting bacteria or viruses, and breaking those organisms down into their constituent proteins and other macromolecules.