The meaning of FISTFUL is handful. How to use fistful in a sentence. handful; a considerable number or amount… See the full definition. Games & Quizzes; Games & Quizzes; Word of the Day; Grammar; Wordplay; Word Finder; Thesaurus; Join MWU; Shop; Books; Merch; Settings; My Words; Recents; Account; Log Out More. Thesaurus; Join MWU ...