DNA hypermethylation in disease: mechanisms and clinical …
Disease-linked DNA hypermethylation can help drive oncogenesis partly by its effects on cancer stem cells and by the CpG island methylator phenotype (CIMP); atherosclerosis by disease-related cell transdifferentiation; autoimmune and neurological diseases through abnormal perturbations of cell memory; and diverse age-associated diseases by age-r...
DNA hypermethylation in disease: mechanisms and clinical …
Disease-linked DNA hypermethylation can help drive oncogenesis partly by its effects on cancer stem cells and by the CpG island methylator phenotype (CIMP); atherosclerosis by disease-related cell transdifferentiation; autoimmune and neurological diseases through abnormal perturbations of cell memory; and diverse age-associated diseases by age ...
DNA甲基化相关高分综述速递 - 知乎 - 知乎专栏
2022年7月1日 · DNA甲基化 （DNA methylation） 是一种关键的表观遗传学机制，通过 DNA甲基转移酶 在二核苷酸的胞嘧啶C-5位添加一个 甲基基团，引起不同基因的转录刺激或抑制，并调节各种细胞功能。 这种DNA化学修饰可以在不改变DNA序列的前提下，改变遗传表现。 DNA甲基化能引起染色质结构、DNA构象、DNA稳定性及DNA与蛋白质相互作用方式的改变，从而控制基因表达。 作为真核细胞正常而普遍的修饰方式，DNA甲基化也是哺乳动物 基因表达调控 的主要表观 …
DNA methylation in mammalian development and disease
2024年8月12日 · Here, we summarize the current understanding of the distinct DNA methylation landscapes that emerge over the mammalian lifespan and discuss how they interact with other regulatory layers to support...
Mechanisms of human DNA methylation, alteration of methylation …
2023年7月30日 · In both aging and cancer, massive hypomethylation of the genome with local hypermethylation is observed. In this review, we will review the current understanding of the mechanisms of DNA methylation and demethylation in humans, the structure and distribution of CpG islands, the role of methylation in the regulation of gene expression ...
Navigating the DNA methylation landscape of cancer
2021年6月10日 · DNA methylation is an important epigenetic modification that defines the properties of cells. Genome-wide hypomethylation, as well as hypermethylation of CpG islands associated with tumor suppressor genes and developmental regulators, are …
DNA hypermethylation modification promotes the development …
2022年5月9日 · In the early stage of HCC, DNA hypermethylation of tumor suppressor genes is predominant. Additionally, DNA hypermethylation in the early stage of HCC changes the binding ability of...
Promoter DNA Hypermethylation and Paradoxical Gene …
2020年3月4日 · We present current evidence documenting promoter hypermethylation and high levels of gene expression, offer insights into the possible mechanisms by which this occurs, and discuss the potential implications for both research and clinical applications.
The Role of Methylation in Gene Expression - Nature
DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression. There are many ways that gene expression is controlled in eukaryotes, but methylation of DNA (not...
DNA Methylation: Genomewide Distribution, Regulatory …
DNA methylation is the most important epigenetic modification involved in the regulation of transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin structure. DNA methylation in the genome is often associated with transcriptional repression and the formation of closed heterochromatin.