Megakaryocytopoiesis - an overview | ScienceDirect Topics
Megakaryocytopoiesis is the process by which megakaryocytes, and ultimately platelets, develop. As with erythropoiesis, the sites of megakaryocytopoiesis change during embryonic and fetal development.
Developmental differences in megakaryocytopoiesis are …
2011年4月14日 · Megakaryocytopoiesis is the process by which hematopoietic stem cells undergo lineage commitment to become megakaryocyte (MK) progenitors, which proliferate and generate immature MKs. These immature MKs then undergo successive rounds of endomitosis that give rise to unique highly polyploid cells.
Megakaryopoiesis - PMC
MEPs are bipotential precursors that give rise to cells of both megakaryocytic and erythroid lineages. Multiple transcription factors including Runx1, Gata1, Fli1 and c-Myb form complex networks that regulate the differentiation of megakaryocytes both positively and negatively.
Megakaryopoiesis - an overview | ScienceDirect Topics
Megakaryocytopoiesis is a continuous developmental process of platelet production, in which hemopoietic stem cells (HSCs) undergo proliferation, differentiation, and maturation. From: Critical Reviews in Oncology/Hematology, 2008
Megakaryopoiesis and platelet production: insight into …
2015年2月1日 · Megakaryopoiesis is a complex process that involves the commitment of hematopoietic stem cells (HSCs) to the megakaryocyte (MK) lineage, proliferation of the progenitors, MK maturation and terminal differentiation that produces platelets.
Megakaryocytopoiesis - an overview | ScienceDirect Topics
Megakaryocytopoiesis. Impaired megakaryocytopoiesis from direct infection of megakaryocytes, immune responses against megakaryocytes, or inflammatory responses in bone marrow. From: Handbook of Small Animal Practice (Fifth Edition), 2008
Advances in megakaryocytopoiesis and thrombopoiesis: from bench …
Megakaryocytopoiesis involves the commitment of haematopoietic stem cells, proliferation and terminal differentiation of megakaryocytic progenitors (MK-p) and maturation of megakaryocytes (MKs) to produce functional platelets.
Genomic landscape of megakaryopoiesis and platelet function …
2016年3月10日 · Megakaryopoiesis is a complex, stepwise process that takes place largely in the bone marrow. At the apex of the hierarchy, hematopoietic stem cells undergo a number of lineage commitment decisions that ultimately lead to the production of polyploid megakaryocytes.
The bone marrow niche from the inside out: how megakaryocytes …
2022年1月27日 · Megakaryocytes (MKs), the largest of the hematopoietic cells, are responsible for producing platelets by extending and depositing long proplatelet extensions into the bloodstream. The traditional view of megakaryopoiesis describes the cellular journey from hematopoietic stem cells (HSCs) along the myeloid branch of hematopoiesis.
Human megakaryocyte progenitor cells - PubMed
Megakaryocytopoiesis is a complex biological process involving a series of cellular events that is initiated with the pluripotent hematopoietic stem cell and eventually results in the biogenesis of platelets shed by mature megakaryocytes (MK). A hierarchy of human MK progenitor cells has been defined by means of studies of in vitro ...
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