Sequestosome 1 - Wikipedia
Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. [5][6][7] Also known as the ubiquitin-binding protein p62, [8] it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy.
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in …
The protein Sequestosome 1 (p62/SQSTM1) is a classical selective autophagy receptor, but it also has roles in the ubiquitin-proteasome system, cellular metabolism, signaling, and apoptosis. p62 is best known for its role in clearing protein aggregates via aggrephagy, but it has recently emerged as a receptor for other forms of selective ...
p62/SQSTM1: ‘Jack of all trades’ in health and cancer - PMC
p62/SQSTM1 interacts with key regulator proteins for diverse signal transduction pathways including mTORC1 activation, NF‐κB signaling, the Keap1‐Nrf2 system, and selective autophagy and serves as a signaling hub for anabolism, inflammatory …
Sequestosome 1/p62: A multitasker in the regulation of malignant …
Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin-proteasome degradation pathway.
p62/SQSTM1, a Central but Unexploited Target: Advances in Its ... - PubMed
2020年9月24日 · p62/SQSTM1, encoded by gene SQSTM1, is widely known as an adaptor protein of selective autophagy to promote aggregate-prone proteins for degradation. It is also a stress-induced scaffold protein involved in Nrf2 activation to resist oxidative stress.
p62/SQSTM1 – steering the cell through health and disease
2018年11月5日 · p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.
p62/SQSTM1-droplet serves as a platform for autophagosome
2021年1月4日 · In this report, we describe the properties of endogenous p62-bodies, the effect of autophagosome biogenesis on these bodies, and the in vivo significance of their turnover. p62-bodies are low-liquidity gels containing ubiquitin and core autophagy-related proteins.
p62/SQSTM1, a Central but Unexploited Target: Advances in Its ...
2020年4月23日 · p62/SQSTM1, encoded by gene SQSTM1, is widely known as an adaptor protein of selective autophagy to promote aggregate-prone proteins for degradation. It is also a stress-induced scaffold protein involved in Nrf2 activation to resist oxidative stress.
SQSTM1 sequestosome 1 [ Homo sapiens (human) ] - National …
2024年12月10日 · Title: Single-cell transcriptomics reveals the intra-tumoral heterogeneity and SQSTM1/P62 and Wnt/β-catenin mediated epithelial to mesenchymal transition and stemness of triple-negative breast cancer.
SQSTM1/p62: A Potential Target for Neurodegenerative Disease
2019年5月15日 · SQSTM1/p62 is a scaffold protein closely involved in the macroautophagy process. p62 functions to anchor the ubiquitinated proteins to the autophagosome membrane, promoting degradation of unwanted molecules.
The role of SQSTM1 (p62) in mitochondrial function and clearance in ...
2021年5月11日 · Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia.
Regulation of the Keap1–Nrf2 pathway by p62/SQSTM1
2016年12月1日 · In this review, we delineate a molecular mechanism of Nrf2-activation by p62/SQSTM1, and describe its physiological role as well as the pathophysiological significance in autophagy-knockout livers and human hepatocellular carcinoma.
P62/SQSTM1 beyond Autophagy: Physiological Role and …
Although there is a meaningful difference between p62/SQSTM1 gene sequences in dogs and humans, the p62 DNA plasmid action shares a similar therapeutic profile with the cancer microenvironments humans and pet dogs . Overall, the p62 DNA plasmid could become a considerable therapeutic or preventive agent for inflammatory-based diseases of ...
p62/SQSTM1 antibody Western, Immunoprecipitation P0068
The p62 protein/sequestosome 1 (SQSTM1) is a multifunctional protein, which binds to ubiquitin. It acts as a scaffold protein for the nuclear factor kappa-B (NF-ΚB) signaling pathway. SQSTM1 also regulates apoptosis and autophagy. Mutations in this gene lead to sporadic and familial Paget disease of bone.
Anti-SQSTM1/p62 antibody produced in rabbit | Sigma-Aldrich
Recombinant fusion protein containing a sequence corresponding to amino acids 1-440 of human SQSTM1 / p62 (NP_001135770.1). Physical form. PBS with 0.02% sodium azide,50% glycerol,pH7.3. Storage and Stability. Store at -20℃. Avoid freeze / thaw cycles.
p62/SQSTM1: 'Jack of all trades' in health and cancer - PubMed
In the present review, we will present the molecular mechanisms behind the control p62 exerts over these pathways, their interconnection and how their deregulation contributes to cancer progression.
Monoclonal Anti-SQSTM1 antibody produced in mouse
Monoclonal Anti-SQSTM1 antibody produced in mouse clone 2C11, purified immunoglobulin, buffered aqueous solution; Synonyms: Anti-PDB3,Anti-ZIP3,Anti-p60,Anti-p62,Anti-sequestosome 1 at Sigma-Aldrich
机械了解SQSTM1 / p62的调节,Autophagy - X-MOL
sqstm1 / p62促进了对各种细胞应激的反应，并与人类疾病有关。该蛋白充当主要的细胞质信号传导枢纽，并具有多个结合伴侣，包括被sqstm1 / p62的zz域（sqstm1 / p62 zz）识别的精氨酸（nt-r）蛋白。我们已经结合生化和nmr方法确定了nt-r识别的分子机理，并获得了与nt-r复合的sqstm1 / p62 zz的晶体结构。
724 Fawn Creek St, Leavenworth, KS 66048 | MLS #2520652 - Zillow
Welcome to this tri-level home, offering 3 spacious bedrooms, 3 full bathrooms, and a non-conforming 4th bedroom in the basement—perfect for a home office, gym, or guest suite. Situated in a desirable neighborhood, this home boasts a thoughtful layout designed for …
The Role of p62/SQSTM1 in Liver Physiology and Pathogenesis
In this review, we discuss the pathophysiological role of p62 in the liver, including formation of hepatic inclusion bodies, cholestasis, obesity, insulin resistance, liver cell death and tumorigenesis.
通过半胱天冬酶A激活caspase-8激活和p62 / SQSTM1 ... - X-MOL
此外，通过激活半胱天冬酶8，木犀草素A还引起Asp329的p62 / SQSTM1蛋白水解。进一步的研究证实，p62中的突变（D329H和D329G）对羟丙甲毒素A介导的p62裂解和凋亡具有抗性。由于缺少与Keap1相互作用的KIR域，切割的p62降低了Nrf2的稳定性，从而导致氧化应激并增加ROS水平。
11+ diagram dd15 sensor locations - KainShasha
2022年11月1日 · Ad Service troubleshooting and wiring for 2007-2016 Detroit DD131516 engines. Engine speed sensor camshaft 11. Detroit Dies...
Fawn Creek Map - Stream - Kansas, United States - Mapcarta
Discover the streams Priest Gully in Queensland, Australia and Lone Cliff Branch in Kentucky, United States . Fawn Creek is a stream in Kansas. Fawn Creek is situated nearby to Blue …
p62/SQSTM1 Accumulation in Squamous Cell Carcinoma of Head …
The p62/SQSTM1 bands were quantified and shown graphically on the right. B) Dose-response curves of SCC35-p62KD, SCC35-control, parental cells (SCC35), and SCC61 cells to MK-2206. C) Detection of p62/SQSTM1 protein expression in panels of SCCHN (Top) and breast cancer cell lines (Middle) by western blotting as described in Methods. Dose ...
Fawn Creek Cemetery Map - Fawn Creek Township, Kansas, USA
Explore unique cemeteries from around the globe. Fawn Creek Cemetery is a cemetery in Fawn Creek Township, Montgomery, Kansas. Mapcarta, the open map.