Polyamine - Wikipedia
Although it is known that the biosynthesis of polyamines is highly regulated, the biological function of polyamines is only partly understood. In their cationic ammonium form, they bind to DNA, and, in structure, they represent compounds with cations that are found at regularly spaced intervals (in contrast to Mg 2+ or Ca 2+, which are point ...
Polyamines: Functions, Metabolism, and Role in Human Disease …
Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses.
Polyamines: their significance for maintaining health and …
2023年12月4日 · This review examines a variety of topics, such as polyamine source and metabolism, including metabolism, transport, and the potential impact of polyamines on health and disease. In addition, a brief summary of the effects of oncogenes and signaling pathways on tumor polyamine metabolism is provided.
Mammalian Polyamine Metabolism and Function - PMC
Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. ...
Polyamines: Functions, Metabolism, and Role in Human …
2021年6月9日 · Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses.
Polyamines: their significance for maintaining health and …
Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mechanisms such as DNA replication, RNA transcription, protein synthesis, and post-translational modification.
Polyamine metabolism and cancer: treatments, challenges and …
2018年9月4日 · Advances in our understanding of the metabolism and molecular functions of polyamines and their alterations in cancer have led to resurgence in the interest of targeting polyamine metabolism as...
Polyamines and Their Metabolism: From the Maintenance of
2022年7月15日 · Polyamines are aliphatic polycations that are present in all cells and play an important role in the mediation of biological functions that are necessary for growth and survival [1,2]. Their discovery dates back to 1678, when spermine …
Polyamines: metabolism and implications in human diseases
Classically, polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation.
Polyamines: their significance for maintaining health and
2023年12月4日 · This review examines a variety of topics, such as polyamine source and metabolism, including metabolism, transport, and the potential impact of polyamines on health and disease. In addition, a brief summary of the effects of oncogenes and signaling pathways on tumor polyamine metabolism is provided.
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