Retinoic acid - Wikipedia
Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A 1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. [2]
Retinoic acid (Vitamin A acid，维生素A酸) - 仅供科研 | RAR激动 …
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC 50 s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through ...
What is Retinoic Acid? - News-Medical.net
2021年3月30日 · Retinoic acid is a light-sensitive compound, like other retinoids, because of the alternating double bonds between the carbon atoms in its hydrophobic tail, which is attached to a 6-carbon ring....
维A酸 - 百度百科
维A酸，分子式为C20H28O2，是体内 维生素A 的 代谢中间产物，主要影响骨的生长和促进 上皮细胞 增生、分化、角质溶解等 代谢 作用。 用于治疗 急性早幼粒细胞白血病 [2]， 寻常痤疮 、 银屑病 、 鱼鳞病 、 扁平苔癣 、 毛发红糠疹 、 毛囊角化病 、 鳞状细胞癌 及 黑色素瘤 等疾病。 口服，10mg/次，2～3次/日。 外用，0.05%～0.1%霜剂或软膏。 局部涂擦，1～2次/日。 药理学：表皮 角质形成细胞 、 黑色素细胞 及真皮 成纤维细胞 都是维A酸作用重要的 靶细胞。 维A酸可 …
維A酸 - 维基百科，自由的百科全书
维A酸 （Tretinoin、ATRA），又称 全反式维甲酸 及 视黄酸，分子式： C 20 H 28 O 2， 分子量 300.44，CAS号302-79-4，熔点180℃，是一種治疗 痤疮 和 急性早幼粒细胞白血病 的药物 [5][6][7]。 對於痤瘡，它以乳霜、凝膠、或軟膏的形式塗抹在皮膚上 [7]。 對於白血病，口服長達三個月 [5]。 局部維A酸也是最廣泛研究的用於 光老化 的類維生素A療法 [8]。 用作乳霜時的常見副作用僅限於皮膚，包括皮膚發紅、脫皮、和對日光敏感 [7]。 口服時，副作用包括 呼吸困难 、 …
Retinoic acid in development: towards an integrated view
2008年6月10日 · Retinoic acid (RA), the active form of vitamin A, is a small lipophilic molecule that acts as a signalling molecule in vertebrates by binding to nuclear receptors (heterodimers of RA receptors...
Retinoic acid in the development, regeneration and maintenance of …
Retinoic acid (RA) is involved in the induction of neural differentiation, motor neuron axon outgrowth and neural patterning during development, but there is growing evidence that RA...
Retinoic Acid and Its Derivatives in Skin - PMC
The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and ...
Retinoic Acid Signaling Pathways in Development and Diseases
Retinoic acid, the main derivative of vitamin A, binds to nuclear receptors, retinoic acid receptor (RAR) and retinoic X receptor (RXR) to regulation gene transcription. RA plays an important role in tissue development and differentiation.
Mechanisms of retinoic acid signalling and its roles in organ
2015年1月5日 · Retinoic acid (RA) signalling has a central role during vertebrate development. RA synthesized in specific locations regulates transcription by interacting with nuclear RA receptors (RARs)...