Succinyl-CoA - Wikipedia
Succinyl-coenzyme A, abbreviated as succinyl-CoA (/ ˌ s ʌ k s ɪ n əl ˌ k oʊ ˈ eɪ /) or SucCoA, is a thioester of succinic acid and coenzyme A.
Succinyl-CoA - an overview | ScienceDirect Topics
Succinyl CoA synthase (SCS) is a mitochondrial matrix enzyme that catalyzes the reversible synthesis of succinate and ATP (or GTP) from succinyl-CoA and ADP in the tricarboxylic acid (TCA) cycle. This enzyme is composed of an α-subunit (SCS-G) and a β-subunit (SCS-A), encoded by the SUCLG1 and SUCLA2 genes respectively.
Succinyl-coenzyme A | C25H40N7O19P3S | CID 92133 - PubChem
Succinyl-CoA is an omega-carboxyacyl-CoA having succinoyl as the S-acyl component. It has a role as an inhibitor, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a coenzyme A. It is a conjugate acid of a succinyl-CoA(5-).
Succinyl-CoA - an overview | ScienceDirect Topics
Succinyl-CoA is known for its role as an intermediate in the TCA cycle in the mitochondria, where it is generated from α-ketoglutarate (also known as oxoglutarate) and coenzyme A through the action of the oxoglutarate dehydrogenase complex (OGDH) and degraded to succinate through the action of the succinyl-CoA synthase complex (SUCL), which is ...
Succinyl-CoA Synthetase is a Phosphate Target for the ...
Succinyl-CoA synthetase (SCS) is the only mitochondrial enzyme capable of ATP production via substrate level phosphorylation in the absence of oxygen, but it also plays a key role in the citric acid cycle, ketone metabolism and heme synthesis.
Succinyl-CoA Synthetase Dysfunction as a Mechanism of ...
Succinyl-CoA synthetase (SCS) is a nuclear-encoded protein complex within the mitochondrial tricarboxylic acid (TCA) cycle, with biallelic pathogenic variants associated with mitochondrial disease in human patients.
The structure of succinyl-CoA synthetase bound to the ...
Keywords: succinyl-CoA synthetase, succinyl-phosphate, cryogenic electron microscopy, catalytic intermediates, ATP-citrate lyase. Abstract. Succinyl-CoA synthetase (SCS) catalyzes a three-step reaction in the citric acid cycle with succinyl-phosphate proposed as a catalytic intermediate.