Thalidomide - ALZFORUM
2021年4月23日 · Thalidomide has been reintroduced and used for a number of immunological and inflammatory disorders, as well as multiple myeloma and other types of cancer. Thalidomide displays anti-angiogenic and immunosuppressive activity. It modulates various cytokines, including inhibiting release of tumor necrosis factor-alpha (TNFα) from monocytes.
Lenalidomide - ALZFORUM
2021年4月23日 · Lenalidomide is structurally similar to thalidomide, and as such is considered a teratogen with the potential to cause birth defects and fetal death. Lenalidomide is being pursued as an alternative to thalidomide, whose development for AD was stopped because of dose-limiting toxicity in elderly patients (Decourt et al., 2017). Both drugs have ...
Timeline - Inflammation - ALZFORUM
Inflammation 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 ...
Therapeutics | ALZFORUM
2015年11月25日 · Find a Therapeutic By Name Go NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24.060 ACI-3024 ACI-35 ACI-7104.056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AIT-101 AKST4290 AL002 AL003 AL044 AL101 ALIA-1758 ...
Getting to First BACE: BACE1 Inhibition Takes a Step Forward
2018年1月5日 · Banner Health is now preparing a Phase 2 clinical trial led by Shen and Sabbagh to test the effectiveness of thalidomide at lowering Aβ, sAPPβ, and BACE1 levels in plasma and CSF, Sabbagh said. They were able to skip a Phase 1 trial, he said, because thalidomide is already an FDA-approved drug, and its safety and side effects, which include ...
Timeline - Small Molecule - ALZFORUM
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Timeline - APP and Amyloid-Related - ALZFORUM
Amyloid-Related 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 ...
Therapeutics Search - ALZFORUM
Find a Therapeutic By Name Go NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24.060 ACI-3024 ACI-35 ACI-7104.056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AIT-101 AKST4290 AL002 …
Therapeutics Search | ALZFORUM
Thalidomide: Thalomid® Alzheimer's Disease (Discontinued) Celgene Corporation: Amyloid-Related, Inflammation: Small Molecule: Trontinemab : RO7126209, RG6102 , Brain shuttle gantenerumab: Alzheimer's Disease (Phase 1/2) Hoffmann-La Roche: Amyloid-Related: Immunotherapy (passive) UB-311: Alzheimer's Disease (Phase 2) United Neuroscience ...
Therapeutics Search | ALZFORUM
Thalidomide: Thalomid® Alzheimer's Disease (Discontinued) Celgene Corporation: Amyloid-Related, Inflammation: Small Molecule: TPN-101: OBP-601, BMS-986001, censavudine, festinavir, 4'-ethynyl stavudine, 4'-ethynyl-d4T: ALS-FTD (Phase 2), Progressive Supranuclear Palsy (Phase 2) Transposon Therapeutics: Inflammation: Small Molecule, DNA/RNA ...