Ambroxol Hydrochloride Improves Motor Functions and Extends
Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis. Front Pharmacol. 2019;10:883. Epub 2019 Aug 7 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Therapeutics | ALZFORUM
2015年11月25日 · Find a Therapeutic By Name Go NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24.060 ACI-3024 ACI-35 ACI-7104.056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AKST4290 AL002 AL003 …
Therapeutics Search - ALZFORUM
Find a Therapeutic By Name Go NSC001 AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac40 ACD856 Acetyl-l-carnitine HCI ACI-24.060 ACI-3024 ACI-35 ACI-7104.056 Acitretin ACP-204 ADEL-Y01 Aduhelm AF 102B Affitope AD02 AGB101 AKST4290 AL002 AL003 AL044 AL101 …
Research Models | ALZFORUM
2024年8月1日 · SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available. This database provides information about selected rodent models of neurodegenerative disease, including Alzheimer’s, Parkinson’s, and ALS. By summarizing, visualizing, and continuously updating ...
Donepezil - ALZFORUM
2023年5月16日 · Donepezil's most common side effects are gastrointestinal, i.e., diarrhea, nausea, and vomiting; dizziness, sleeplessness/fatigue, and urinary incontinence also have been reported. These are known class effects of cholinergic therapies, and often occur primarily at the beginning of treatment. One post-hoc analysis reported an inverse ...
Large Phase 2 Trial Starting Up in Genetic Parkinson’s Population
2014年6月13日 · A Phase 2 trial has been approved by the Food and Drug Administration and will begin enrolling this month, with completion scheduled for 2022, Sardi said. The study will enroll about 230 people who have Parkinson’s and a GBA mutation. Although this initial trial only includes mutation carriers, the researchers believe the strategy may work to ...
Parkinson’s Treatments Go After Genetic Targets | ALZFORUM
Other researchers are developing the cough medicine Ambroxol as a GBA therapy. In Turin, Anthony Schapira of University College London explained that Ambroxol seems to act as a chaperone, binding mutant GBA in the endoplasmic reticulum and escorting it through the Golgi apparatus to the lysosome for degradation. In cellular and animal models of ...
Therapeutics Search - ALZFORUM
apomorphine hydrochloride sublingual thin film: Parkinson's Disease (Approved) Sunovion Pharmaceuticals Inc. Other Neurotransmitters: Small Molecule: Ladostigil: Ladostigil hemitartrate, TV3326: Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) Avraham Pharmaceuticals Ltd: Cholinergic System: Small Molecule: Lanabecestat ...
Blarcamesine - ALZFORUM
2016年1月15日 · Overview. Name: Blarcamesine Synonyms: Anavex 2-73 Chemical Name: Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride Therapy Type: Small Molecule Target Type: Other Condition(s): Alzheimer's Disease, Parkinson's Disease Dementia, Parkinson's Disease U.S. FDA Status: Alzheimer's Disease (Phase 2/3), Parkinson's Disease …
GV1001 | ALZFORUM
Originally developed as a cancer vaccine, GV1001 is a 16-amino-acid peptide comprising a sequence from the human enzyme telomerase reverse transcriptase (TERT). Most cancers highly express TERT, and immunization with GV1001 aims to activate the immune system to recognize and kill cancer cells. GV1001 was approved in Korea for immunotherapy of ...