Excitability tuning of axons in the central nervous system
2015年10月22日 · By systematic efforts to directly record ionic channels along axon, axonal bleb recording approach revealed important aspects for understanding axon physiology including the distribution of maximal conductance and difference in gating kinetics of voltage-dependent Na + channels, as well as the exact site of spike initiation in the AIS.
Axon-Seq Decodes the Motor Axon Transcriptome and Its …
2018年12月11日 · Spinal motor axons traverse large distances to innervate target muscles, thus requiring local control of cellular events for proper functioning. To interrogate axon-specific processes we developed Axon-seq, a refined method incorporating microfluidics, RNA sequencing (RNA-seq), and bioinformatic qua …
Membrane mechanics dictate axonal pearls-on-a-string ... - Nature
2024年12月2日 · In silico modeling suggests that this axon nanopearling can be explained by membrane mechanical properties. Treatments disrupting membrane properties, such as hyper- or hypotonic solutions,...
When Things Go Awry in Axons - Frontiers for Young Minds
2022年8月29日 · In the last three decades, neuro-scientists found that, through a microscope, the axon degeneration in the nerves of diseased patients looks like Wallerian degeneration. This is why they call the axon demise in neurodegenerative disease Wallerian-like degeneration, even though cutting of axons is not involved.
What axons tell each other: axon–axon signaling in nerve and …
2013年12月1日 · Axon–axon recognition, as a precursor to all of these events, can simply involve expression of complementary adhesive codes — but can also entail intricate neural activity and second messenger-controlled differences in adhesive codes that effectively generate large assortments of axonal identities, each extending from a neuron with a ...
On Myelinated Axon Plasticity and Neuronal Circuit Formation …
2017年10月10日 · We highlight the observations that neuronal activity can rapidly tune axonal diameter, promote re-entry of oligodendrocyte progenitor cells into the cell cycle, or drive their direct differentiation into oligodendrocytes.
Axon Initial Segment Structure and Function in Health and Disease
2024年10月31日 · This process-converting synaptic input into AP output-typically occurs in a specialized region of axon termed the axon initial segment (AIS). The AIS, as its name implies, is often contained to the first section of axon abutted to the soma and is home to a dizzying array of ion channels, attendant scaffolding proteins, intracellular organelles ...
Axons: Essential Connectors of Neural Communication
2024年9月30日 · Billions of microscopic highways, known as axons, form an intricate network that enables lightning-fast communication between neurons, making them the unsung heroes of our brain’s remarkable ability to think, feel, and remember.
Axons, dendrites, and synapses | SpringerLink
2023年5月10日 · Axons and dendrites make contact with each other at axo-dendritic synapses, and dendro-dendritic synapses are also possible. These structures allow neurons to communicate in different ways, and to transmit information to other nerve cells, muscle, or gland cells.
Excitability tuning of axons in the central nervous system
Configurations of subcellular recordings from axons. a Recording from axon terminals/boutons.b Recording from axonal bleb, a spherical structure formed at the cut end of axons by tissue slicing procedures.c Recording from the intact axon shaft. Another approach to assess the ionic channels in the axon is to record from axonal blebs (Fig. 2b). …