BRCA Gene Changes: Cancer Risk and Genetic Testing
Does the likelihood of having a BRCA gene mutation differ among populations? Who should consider genetic counseling and testing for inherited harmful changes in BRCA1 and BRCA2 ? How is genetic testing for harmful changes in BRCA1 and BRCA2 done?
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks associated with BRCA1/BRCA2, screening, risk-reduction, treatment, and prognosis.
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
Apr 15, 2024 · Those with harmful BRCA1 or BRCA2 changes who had the surgery, the study found, had a lower risk of dying from ovarian cancer and breast cancer than those who didn’t. Results from both studies were published February 29 in JAMA Oncology.
Mutaciones en el gen BRCA: el riesgo de cáncer y las pruebas …
Hoja informativa sobre los genes BRCA1 y BRCA2, qué hacer si la prueba de una persona indica que tiene cambios en uno de estos genes y las consecuencias de las pruebas genéticas.
Discovery – BRCA Connection to Breast and Ovarian Cancer
NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer. From this research, a screening test was also developed to help patients make informed decisions about their health.
Olaparib Approved for Breast Cancers with BRCA Gene Mutations
Jan 29, 2018 · The Food and Drug Administration has approved olaparib (Lynparza®) to treat metastatic breast cancers that have inherited mutations in the BRCA1 or BRCA2 genes as well as a companion diagnostic test for selecting candidates for the therapy.
Definition of BRCA1 gene - NCI Dictionary of Cancer Terms
A gene that makes a protein that repairs damaged DNA. Mutations (changes) in the BRCA1 gene significantly increase the risk of developing breast and ovarian cancer.
Cancer Risk for Women Carrying BRCA Mutations - NCI
Jul 12, 2017 · Women who know they have inherited a harmful BRCA1 or BRCA2 mutation can take steps to reduce their risk of breast and ovarian cancer. But any preventive measures—including intensive early surveillance , use of chemoprevention , and prophylactic surgery —come with their own risks.
Olaparib for Pancreatic Cancer with BRCA Mutations - NCI
Jun 26, 2019 · Olaparib (Lynparza) may benefit some people with advanced pancreatic cancer who have BRCA1 or BRCA2 mutations, according to the POLO trial results.
BRCA Exchange serves as global data resource on gene variants
Jan 9, 2019 · The BRCA Exchange, a global resource that includes data on thousands of variants in the BRCA1 and BRCA2 genes, is available to the public through a website and new smartphone app.