BufferGel - Wikipedia
BufferGel is the brand name of a spermicide and microbicide gel which is being tested for its potential development into a preventive medicine to stop the transmission of HIV .
Safety and Tolerability of BufferGel, a Novel Vaginal Microbicide…
2001年2月1日 · BufferGel (ReProtect, LLC) is a vaginal gel with an acidic buffering action that was designed to prevent vaginal neutralization by semen. The purpose of this study was to evaluate the safety and tolerability of BufferGel (ReProtect, Limited Liability Company) applied vaginally either once or twice daily by 27 women who were at low risk for ...
Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for …
2011年4月24日 · Objective: To determine the safety and effectiveness of BufferGel and 0.5% PRO2000 microbicide gels for the prevention of male-to-female HIV transmission. Design: Phase II/IIb, randomized, placebo-controlled trial with three double-blinded gel arms and an …
Anti-HIV Gel Shows Promise in Large-scale Study in Women
The clinical trial tested two candidate microbicide gels for safety and their ability to prevent HIV infection: PRO 2000 (0.5 percent dose), and BufferGel (ReProtect Inc., Baltimore). The U.S. Agency for International Development provided funding to …
HPTN 035 phase II/IIb randomised safety and effectiveness ... - PubMed
Objectives: To estimate the effectiveness of candidate microbicides BufferGel and 0.5% PRO 2000 Gel (P) (PRO 2000) for prevention of non-ulcerative sexually transmitted infections (STIs).
BufferGel 和 PRO 2000/5：预防女性感染 HIV 的阴道凝胶 - ICH GCP
2003年12月11日 · 阴道杀菌剂 BufferGel 和 0.5% PRO 2000/5 Gel (P) 预防女性 HIV 感染的 II/IIb 期安全性和有效性研究. 全世界大多数 HIV 感染者通过异性接触感染了该病毒。. BufferGel 和 PRO 2000 Gel 是阴道凝胶，旨在防止女性在与感染 HIV 的伴侣发生性行为时感染 HIV。. 这项研究将测 …
HPTN 035 Phase II/IIb Randomized Safety and Effectiveness Study …
BufferGel was designed to exploit the natural defence against cervicovaginal infections found in acidic vaginal fluid 11,12 by maintaining an acidic pH in the vagina despite the presence of an alkaline ejaculate and was shown effective against Neisseria gonnorrhoeae (GC) and Chlamydia trachomatis (CT) in vitro and in some 13–15 but not all ...
Safety and effectiveness of BufferGel and 0.5% PRO2000 gel f ... - LWW
BufferGel and PRO2000 gel are two novel vaginal products that showed good acceptability and short-term safety in phase I and phase II trials conducted in the USA , Europe , India , and several countries in Africa [14,16,18,19].
A Phase I study of the functional performance, safety and acceptability ...
2008年2月1日 · BufferGel is an acidic aqueous gel with buffering capacity provided by carbomer, a crosslinked polyacrylic acid. The aqueous gel is formulated at pH 3.85, with pH and osmolality adjusted with physiological salts.
BufferGel and PRO2000 gel are two novel vaginal products that showed good acceptability and short-term safety in phase I and phase II trials conducted in the USA
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