CD8 + T cell differentiation and dysfunction in cancer - Nature
2021年7月12日 · Here we review CD8 + T cell differentiation to dysfunctional states during tumorigenesis. We highlight similarities and differences between T cell dysfunction and other …
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate …
CD8 + T cell differentiation and dysfunction in cancer - PubMed
Here we review CD8 + T cell differentiation to dysfunctional states during tumorigenesis. We highlight similarities and differences between T cell dysfunction and other hyporesponsive T …
Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation ...
2020年10月5日 · T cells follow a triphasic distinct pathway of activation, proliferation and differentiation before becoming functionally and phenotypically "exhausted" in settings of …
Epigenetic control of CD8+ T cell differentiation - PMC
In this Review, we summarize our current understanding of the epigenetics of CD8 + T cell differentiation, specifically exploring the influence of progressive changes in DNA methylation, …
The timing of differentiation and potency of CD8 effector …
2022年4月27日 · Here we show that the RNA binding proteins (RBP) ZFP36 and ZFP36L1 limit the rate of differentiation of activated naïve CD8+ T cells and the potency of the resulting …
Immunometabolism of CD8 + T cell differentiation in cancer
CD8 + cytotoxic T lymphocytes (CTLs) are central mediators of tumor immunity and immunotherapies. Upon tumor antigen recognition, CTLs differentiate from naive/memory-like …
CD8+ T-cell differentiation and dysfunction inform treatment …
2024年9月12日 · Bone marrow CD8 + T-cell differentiation states play a crucial role in patients with AML response to therapy. Single-cell RNA sequencing analysis reveals developmental …
Cytokines and the Inception of CD8 T Cell Responses - PMC
Naïve CD8 T cells have the potential to differentiate into both short-lived effectors and memory precursors following activation. Short-lived effector cells are commonly defined as CD127 lo, …
CD8 + T cells in the cancer-immunity cycle - Cell Press
2023年10月10日 · We discuss factors that influence CD8 + T cell differentiation and function in cancer through a framework that incorporates the classic three-signal model and a fourth …