CXCR2 expression on granulocyte and macrophage progenitors …
2019年8月8日 · Here, we reported that granulocyte and macrophage progenitor cells (GMPs) express CXCR2, and CXCR2 deficiency reduces the ability of GMPs to give rise to macrophage and dendritic cell...
CXCR2 deficient mice display macrophage-dependent exaggerated acute ...
2017年2月16日 · Here we demonstrate that CXCR2-deficient mice display a counterintuitive transient exaggerated inflammatory response to cutaneous and peritoneal inflammatory stimuli.
CXCR2 Receptor: Regulation of Expression, Signal Transduction, …
CXCR2 ligands, upon binding to the receptor, induce recruitment and enhance the pro-tumor properties of tumor-associated macrophages (TAM) [153,154,155]. Recruitment of these cells is associated with CXCR2 expression on CD14 monocytes [ 156 ].
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade ... - PubMed
2019年8月20日 · Strikingly, CXCR2 knockout monocytes infused in Pten pc-/-; Trp53 pc-/- mice differentiated in tumor necrosis factor alpha (TNF-α)-releasing pro-inflammatory macrophages, leading to senescence and tumor inhibition. Mechanistically, PTEN-deficient tumor cells are vulnerable to TNF-α-induced senescence, because of an increase of TNFR1.
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade …
2019年8月8日 · In the present paper we identify the macrophage receptor CXCR2 and CXCR2 signaling as major drivers of TAMs polarization in prostate tumors, and we propose a therapeutic strategy based on blockade of the CXCL-CXCR2 pathway or infusion of CXCR2 knockout (KO) monocytes to harness the anti-tumorigenic potential of macrophages against prostate cancer.
CXCR2 expression on granulocyte and macrophage progenitors …
2019年8月8日 · Here, CXCR2 expression on granulocyte and macrophage progenitor cells (GMPs) was found to participate in myeloid cell differentiation within the tumor environment. In CXCR2-deficient tumor-bearing mice, GMPs exhibited fewer macrophage and dendritic cell progenitor cells than wild-type tumor-bearing mice, thereby decreasing monocytic MDSCs (mo ...
Blocking the CXCL1-CXCR2 axis enhances the effects of ... - Nature
2023年4月10日 · It has been shown that blocking CXCL1-CXCR2 inhibits tumour progression and reduces macrophage recruitment in the TME. The combination regimen has been shown to synergistically reduce the...
(CXCR2), and activation of this receptor through CXCL2 polarizes macrophages toward an anti-in-flammatory phenotype. Notably, pharmacological blockade of CXCR2 receptor by a selective antagonist promoted the re-education of TAMs to-ward a pro-inflammatory phenotype. Strikingly, CXCR2 knockout monocytes infused in Ptenpc /;
CXCR2 expression on granulocyte and macrophage progenitors …
2019年8月8日 · CXCR2 deficiency increased SAP18 expression in tumor-bearing mice, which reduced STAT3 phosphorylation through restraining ERK1/2 activation. Our findings reveal a critical role for CXCR2 in regulating hematopoietic progenitor cell differentiation under tumor conditions, and SAP18 is a key negative regulator in this process.
Tumor-Associated Macrophages Affect the Tumor …
These results lend credence to the hypothesis that overexpression of chemokine CXCL6 and its receptor CXCR2 in the tumor microenvironment is crucial for HCC development and progression, suggesting that dysregulated CXCL6/CXCR2 signaling facilitates tumour-associated macrophage (TAM) activation.